Translational Approaches to Septic Cardiomyopathy

Status:	Active, not recruiting
Conditions:	Cardiology, Hospital
Therapuetic Areas:	Cardiology / Vascular Diseases, Other
Healthy:	No
Age Range:	18 - Any
Updated:	12/26/2018
Start Date:	May 19, 2017
End Date:	October 27, 2019

This translational study will assess the association between septic cardiomyopathy (measured
via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and
(b) the behavior of cardiomyocytes derived from inducible pluripotent stem cells.

INCLUSION CRITERIA

At least 18 years of age Admitted to the ICU

SEPSIS PATIENTS:

Sepsis patients must have:

1. Suspected or confirmed infection AND

2. Organ dysfunction as defined by a SOFA >= 2 above baseline (if no baseline data
available, SOFA assumed to be 0)

OR

SEPTIC SHOCK PATIENTS:

AFTER INFUSION OF 20ML/KG CRYSTALLOID OR EQUIVALENT, septic shock patients must have:

1. Suspected or confirmed infection AND

2. Lactate > 2 mmol/L AND

3. Receiving vasopressors

EXCLUSION CRITERIA Known pregnancy Primary diagnosis of acute coronary syndrome Known
preexisting heart disease Known severe valvular disease (regurgitation or stenosis)

Major cardiac dysrhythmia such as:

- Ventricular tachycardia (V-tach)

- Ventricular Fibrillation (V-fib)

- Third degree heart block (complete hear block or complete AV block)

We found this trial at

sites

Stanford University

450 Serra Mall
Stanford, California 94305

(650) 723-2300