Virtual Reality- Working Memory Retraining
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 3/7/2019 |
| Start Date: | February 1, 2019 |
| End Date: | July 31, 2019 |
| Contact: | Holly D Pothier, M.S.W. |
| Email: | holly.pothier@va.gov |
| Phone: | 415-221-4810 |
Effects of Active Virtual Reality Working Memory Retraining on Heavy Drinking Veterans With Mild Traumatic Brain Injury
This study will establish the acceptability and feasibility of enrolling and retaining heavy
drinking Veterans with mild traumatic brain injury (mTBI) in an 8-week, randomized cross-over
design trial of active VR working memory retraining (WMR). This study will also seek to
establish the efficacy of active VR-WMR to increase performance in executive function.
drinking Veterans with mild traumatic brain injury (mTBI) in an 8-week, randomized cross-over
design trial of active VR working memory retraining (WMR). This study will also seek to
establish the efficacy of active VR-WMR to increase performance in executive function.
The investigators will employ a physically active VR working memory retraining (VR-WMR)
regimen utilizing components of Blue Goji VR Active Gaming. The synthesis of physical
activity and an enriched VR environment is expected to yield superior working memory training
stemming from greater neurological activation. This enhanced working memory training task
will result in greater motivation to engage and complete a training regimen, thus fostering
greater improvements in executive function than traditional working memory training tasks;
ultimately resulting in increased self-control over alcohol use and other high-risk
behaviors.
regimen utilizing components of Blue Goji VR Active Gaming. The synthesis of physical
activity and an enriched VR environment is expected to yield superior working memory training
stemming from greater neurological activation. This enhanced working memory training task
will result in greater motivation to engage and complete a training regimen, thus fostering
greater improvements in executive function than traditional working memory training tasks;
ultimately resulting in increased self-control over alcohol use and other high-risk
behaviors.
Inclusion Criteria:
- must report "heavy" drinking by NIH/NIAAA criteria (>7 drinks/week for women; >14
drinks/week for men) for at least one week in the last 90 days
- must meet moderate to severe criteria for current (past year) alcohol use disorder
(AUD) by DSM-5
- must express a desire to reduce, stop, or maintain cessation of alcohol use
- must report a history of TBI as defined by American Congress of Rehabilitation
Medicine (ACRM), in the chronic, stable phase of recovery (>6 months from injury)
Exclusion Criteria:
- Unstable medical or psychiatric disorders judged to be unstable in the clinical
judgment of the PI
- Current or past history of intrinsic cerebral tumors, HIV infection, cerebrovascular
accident, aneurysm, arteriovenous malformations, myocardial infarction,
cerebrovascular or peripheral vascular disease, type-1 diabetes, any cardiac, hepatic
or renal diseases/disorders, surgical implantation of neurostimulators or cardiac
pacemakers, medically diagnosed chronic obstructive pulmonary disease, demyelinating
and neurodegenerative diseases, history of seizure disorder, and/or any physical
disability making it impossible to use exercise equipment
- No female participant will be pregnant or attempting to conceive
- Concurrent participation in an AUD, cognitive training, or exercise study
- Must not require acute medical detoxification from alcohol (CIWA-AD > 11) within the
past week prior to study entry
- Subjects who, in the opinion of the investigator, are otherwise unsuitable for a study
of this type will be excluded
We found this trial at
1
site
San Francisco, California 94121
Principal Investigator: David L Pennington, PhD
Phone: 415-221-4810
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