Quality of Life in Postmenopausal Women Who Are Receiving Either Exemestane or Anastrozole With or Without Celecoxib for Stage I, Stage II, or Stage IIIA Primary Breast Cancer
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any - 120 |
| Updated: | 1/3/2019 |
| Start Date: | December 2004 |
| End Date: | January 30, 2013 |
Quality Of Life Companion Study For JMA27 (NCIC-MA.27): A Randomized Phase III Trial Of Exemestane Versus Anastrozole With Or Without Celecoxib In Postmenopausal Women With Receptor Positive Primary Breast Cancer
RATIONALE: Quality-of-life assessment in postmenopausal women who are receiving hormone
therapy for breast cancer may help to determine the effects of treatment on these patients
and may improve the quality of life for future breast cancer patients.
PURPOSE: This clinical trial is studying quality of life of postmenopausal women who are
receiving either exemestane or anastrozole with or without celecoxib for stage I, stage II,
or stage IIIA primary breast cancer.
therapy for breast cancer may help to determine the effects of treatment on these patients
and may improve the quality of life for future breast cancer patients.
PURPOSE: This clinical trial is studying quality of life of postmenopausal women who are
receiving either exemestane or anastrozole with or without celecoxib for stage I, stage II,
or stage IIIA primary breast cancer.
OBJECTIVES:
Primary
- Compare treatment-related symptoms using the Functional Assessment of Cancer
Therapy-Endocrine Symptoms (FACT-ES) questionnaire in postmenopausal women with
receptor-positive stage I, II, or IIIA primary breast cancer undergoing treatment with
exemestane vs anastrozole with or without celecoxib on protocol CAN-NCIC-MA27.
Secondary
- Compare health-related quality of life using the FACT-ES questionnaire in patients
treated with these regimens.
- Determine the extent to which differences in treatment-emergent symptoms affect overall
quality of life in patients treated with these regimens.
OUTLINE: This is a multicenter, companion study. Patients receive treatment on CAN-NCIC-MA27.
Health-related quality of life and treatment-related symptoms are assessed using the
Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES) questionnaire at
baseline and at 3, 6, 12, and 24 months.
PROJECTED ACCRUAL: A total of 1,253 patients will be accrued for this study.
Primary
- Compare treatment-related symptoms using the Functional Assessment of Cancer
Therapy-Endocrine Symptoms (FACT-ES) questionnaire in postmenopausal women with
receptor-positive stage I, II, or IIIA primary breast cancer undergoing treatment with
exemestane vs anastrozole with or without celecoxib on protocol CAN-NCIC-MA27.
Secondary
- Compare health-related quality of life using the FACT-ES questionnaire in patients
treated with these regimens.
- Determine the extent to which differences in treatment-emergent symptoms affect overall
quality of life in patients treated with these regimens.
OUTLINE: This is a multicenter, companion study. Patients receive treatment on CAN-NCIC-MA27.
Health-related quality of life and treatment-related symptoms are assessed using the
Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES) questionnaire at
baseline and at 3, 6, 12, and 24 months.
PROJECTED ACCRUAL: A total of 1,253 patients will be accrued for this study.
DISEASE CHARACTERISTICS:
- Histologically confirmed invasive breast cancer
- pT1-3; pNX, pN0-2 or pN3*; M0 NOTE: *Only when the sole basis for this
classification is the presence of 10 or more involved axillary lymph nodes
- Registered on protocol CAN-NCIC-MA27 within the past week
- Hormone receptor status:
- Estrogen receptor- and/or progesterone receptor-positive by immunohistochemistry
or tumor receptor content ≥ 10 fmol/mg protein
- At least 1 tumor must be receptor-positive in patients with bilateral breast
cancer
PATIENT CHARACTERISTICS:
Age
- Postmenopausal
Performance status
- ECOG 0-2
Sex
- Female
Menopausal status
- Postmenopausal
Life expectancy
- Not specified
Hematopoietic
- Not specified
Hepatic
- Not specified
Renal
- Not specified
Other
- Able to read, understand, and complete quality of life questionnaires
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- Not specified
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified
We found this trial at
224
sites
401 Matthew St
Marietta, Ohio 45750
Marietta, Ohio 45750
(740) 376-5000
Strecker Cancer Center at Marietta Memorial Hospital The Memorial Health System's Strecker Cancer Center combines...
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1300 Morris Park Avenue
Bronx, New York 10461
Bronx, New York 10461
718.430.2302
Albert Einstein Cancer Center at Albert Einstein College of Medicine The Albert Einstein Cancer Center...
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Cleveland Clinic Taussig Cancer Center At Taussig Cancer Institute, more than 250 highly skilled doctors,...
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3535 Olentangy River Road
Columbus, Ohio 43214
Columbus, Ohio 43214
(614) 566-5000
Riverside Methodist Hospital Cancer Care Serving central Ohio since 1892, Riverside Methodist is consistently ranked...
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4725 North Federal Highway
Fort Lauderdale, Florida 33308
Fort Lauderdale, Florida 33308
(954) 492-5764
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Holy Cross Hospital's Michael...
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1920 Libal Street
Green Bay, Wisconsin 54307
Green Bay, Wisconsin 54307
(920) 433-8889
St. Vincent Hospital Regional Cancer Center Our group of 19 oncologists, including the region's only...
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1150 N 35th Ave # 330
Hollywood, Florida 33021
Hollywood, Florida 33021
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1240 S Old Dixie Hwy
Jupiter, Florida 33458
Jupiter, Florida 33458
(561) 263-4400
Ella Milbank Foshay Cancer Center at Jupiter Medical Center The Foshay Cancer Center is one...
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Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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1800 West Charleston Boulevard
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
(702) 383-2000
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
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CCOP - Mount Sinai Medical Center The Mount Sinai Community Clinical Oncology Program (MSCCOP) is...
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825 N Emporia Ave
Wichita, Kansas 67214
Wichita, Kansas 67214
(316) 261-3200
Via Christi Cancer Center at Via Christi Regional Medical Center Via Christi Health's rich history...
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Hickman Cancer Center at Bixby Medical Center At ProMedica Bixby Hospital, we
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1351 Kimberly Rd
Bettendorf, Iowa 52722
Bettendorf, Iowa 52722
(563) 355-7733
Hematology Oncology Associates of the Quad Cities
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2900 12th Ave N Ste 160W
Billings, Montana 59101
Billings, Montana 59101
(406) 238-6290
Hematology-Oncology Centers of the Northern Rockies - Billings The physicians and staff of Hematology-Oncology Centers...
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Bismarck Cancer Center The Bismarck Cancer Center (BCC) is a joint venture between Sanford Health...
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Wood County Oncology Center The Cancer Care Center at Wood County Hospital opened March 2014,...
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Bozeman Deaconess Hospital Bozeman Deaconess Hospital is a Joint Commission certified, licensed Level III trauma...
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Bryn Mawr Hospital Bryn Mawr Hospital, a nationally recognized community teaching hospital, is conveniently located...
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Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
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Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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Cleveland, Ohio 44106
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CCOP - Columbus As one of the original 20 CCOPs, the Columbus Community Clinical Oncology...
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11850 Blackfoot St. NW
Suite 130
Coon Rapids, Minnesota 55433
Coon Rapids, Minnesota 55433
763-236-0808
Mercy and Unity Cancer Center at Mercy Hospital The Virginia Piper Cancer Institute - Mercy...
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Grandview Hospital You'll feel like part of our family when you visit Grandview Medical Center...
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Samaritan North Cancer Care Center At Good Samaritan Hospital (GSH), our licensed, board-certified staff uses...
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2300 N. Edward Street
Decatur, Illinois 62526
Decatur, Illinois 62526
217-876-8121
Decatur Memorial Hospital Cancer Care Institute An American flag bearing only 48 stars waved above...
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Grady Memorial Hospital As the center of healthcare in Delaware County, Grady Memorial Hospital is...
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300 East Locust St., Ste 350
Des Moines, Iowa 50309
Des Moines, Iowa 50309
(515) 244-7586
CCOP - Iowa Oncology Research Association The Iowa Oncology Research Association (IORA) was established by...
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1221 Pleasant St
Des Moines, Iowa 50309
Des Moines, Iowa 50309
(515) 241-4141
John Stoddard Cancer Center at Iowa Methodist Medical Center Iowa's first children's cancer center opened...
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
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411 Laurel St New Visions
Des Moines, Iowa 50314
Des Moines, Iowa 50314
(515) 247-3970
Medical Oncology and Hematology Associates at Mercy Cancer Center When it comes to cancer care,...
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411 Laurel Street
Des Moines, Iowa 50314
Des Moines, Iowa 50314
(515) 247-3121
Mercy Cancer Center at Mercy Medical Center - Des Moines When it comes to cancer...
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Cancer Center of Kansas, PA - Dodge City Dr. H.E. Hynes founded Cancer Center of...
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CCOP - Duluth The Duluth CCOP, established and funded by the National Cancer Institute (NCI)...
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Miller - Dwan Medical Center Essentia Health-Duluth, located in the Miller-Dwan building, is a 165-bed...
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Fairview Southdale Hospital Fairview Health Services is an award-winning nonprofit health care system based in...
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Cancer Center of Kansas, PA - El Dorado Dr. H.E. Hynes founded Cancer Center of...
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Elkhart General Hospital For over 100 years, the highly skilled professionals of Elkhart General Hospital...
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Blanchard Valley Medical Associates Blanchard Valley Medical Associates was founded in 1974 by Dr. William...
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Front Range Cancer Specialists At Front Range Cancer Specialists, we are dedicated to providing quality...
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Poudre Valley Hospital A 270-bed regional medical center offering a wide array of treatments, surgeries,...
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550 Osborne Road
Fridley, Minnesota 55432
Fridley, Minnesota 55432
763-236-5000
Mercy and Unity Cancer Center at Unity Hospital Patients and their families are the heart...
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Northeast Georgia Medical Center Northeast Georgia Health System (NGHS) is a not-for-profit community health system...
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Great Falls Clinic Founded in 1917, the Great Falls Clinic is the fourth oldest medical...
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North Colorado Medical Center NCMC is a fully accredited, private, non-profit facility licensed to operate...
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Legacy Mount Hood Medical Center Legacy Mount Hood Medical Center, East County's full-service community hospital,...
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St. Peter's Hospital Welcome to St. Peter’s Hospital, providing premier health care to a five–county...
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Pardee Memorial Hospital Pardee Hospital is a not-for-profit community hospital founded in 1953 and is...
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Hutchinson Area Health Care Hutchinson Health is a team of medical professionals and support staff...
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Borgess Medical Center At Borgess, healing is our calling. This is the place where people...
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