Evaluating the Effects of Surgical and Non-Surgical Treatment Options in People With Emphysema
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease, Pulmonary, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 35 - 90 |
| Updated: | 1/9/2019 |
| Start Date: | January 2000 |
| End Date: | December 2020 |
Emphysema: Outcomes and Technology Assessment
Emphysema is a lung disease that involves damage to the air sacs in the lungs and can lead to
breathing difficulties. Treatment options for people with emphysema include pulmonary
rehabilitation, lung volume reduction surgery, and lung transplantation. This study will
observe people with emphysema to assess the effect of these treatment therapies on their
quality of life and long-term health.
breathing difficulties. Treatment options for people with emphysema include pulmonary
rehabilitation, lung volume reduction surgery, and lung transplantation. This study will
observe people with emphysema to assess the effect of these treatment therapies on their
quality of life and long-term health.
Emphysema is a progressive lung disease that results in shortness of breath and a reduced
capacity for physical activity. It is caused by inflammation within the small air sacs and
small airways of the lungs, which can lead to the destruction of the air sac walls and
eventually to airway collapse. Treatment options for emphysema include both non-surgical and
surgical interventions. Pulmonary rehabilitation, a non-surgical treatment, includes a
combination of education, exercise training, nutrition advice, and smoking cessation
programs. The goal of pulmonary rehabilitation is to increase exercise tolerance and reduce
breathing difficulties. Two surgical treatment options include lung volume reduction surgery,
in which small amounts of damaged lung tissue are removed, and lung transplantation, in which
a person's damaged lung is replaced with a healthy lung from a donor. While these surgical
options may offer potential improvements in quality of life, they also impose substantial
risks, including infections, pneumonia, or even death. In this study, researchers will follow
participants over a long period of time to assess the effects of pulmonary rehabilitation,
lung volume reduction surgery, and lung transplantation on health outcomes and quality of
life.
This study will enroll people with moderate to severe emphysema who have undergone pulmonary
rehabilitation, lung volume reduction surgery, or lung transplantation. Participants will
attend annual study visits and will complete computerized interviews and health-related
questionnaires that will assess quality of life factors. Study researchers will also review
participants' medical records to collect information on lung function and blood test results.
capacity for physical activity. It is caused by inflammation within the small air sacs and
small airways of the lungs, which can lead to the destruction of the air sac walls and
eventually to airway collapse. Treatment options for emphysema include both non-surgical and
surgical interventions. Pulmonary rehabilitation, a non-surgical treatment, includes a
combination of education, exercise training, nutrition advice, and smoking cessation
programs. The goal of pulmonary rehabilitation is to increase exercise tolerance and reduce
breathing difficulties. Two surgical treatment options include lung volume reduction surgery,
in which small amounts of damaged lung tissue are removed, and lung transplantation, in which
a person's damaged lung is replaced with a healthy lung from a donor. While these surgical
options may offer potential improvements in quality of life, they also impose substantial
risks, including infections, pneumonia, or even death. In this study, researchers will follow
participants over a long period of time to assess the effects of pulmonary rehabilitation,
lung volume reduction surgery, and lung transplantation on health outcomes and quality of
life.
This study will enroll people with moderate to severe emphysema who have undergone pulmonary
rehabilitation, lung volume reduction surgery, or lung transplantation. Participants will
attend annual study visits and will complete computerized interviews and health-related
questionnaires that will assess quality of life factors. Study researchers will also review
participants' medical records to collect information on lung function and blood test results.
Inclusion Criteria:
- Diagnosed with emphysema
- Referred for pulmonary rehabilitation, lung volume reduction surgery, or lung
transplantation
Exclusion Criteria:
- Non-obstructive lung disease
- Chronic obstructive pulmonary disease (COPD) that is not predominantly due to
emphysema
- Inability to read English
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