Standing Computed Tomography (SCT) Imaging of the Knee Joint
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 45 - 92 |
| Updated: | 1/10/2019 |
| Start Date: | March 1, 2016 |
| End Date: | April 1, 2020 |
Standing Computerized Tomography (SCT) Imaging of the Knee Joint in People With or at Risk for Knee Osteoarthritis (KOA)
This study will help us decide the best way to image the knee for diagnostic purposes: Knee
computed tomography vs knee x-ray. The computed tomography will provide a weight bearing 3D
view.
computed tomography vs knee x-ray. The computed tomography will provide a weight bearing 3D
view.
This will be an ancillary study to the Multicenter Osteoarthritis Study (MOST) second renewal
#201511711). Using a prototype Curve Beam Standing Computed Tomography (SCT) scanner to get a
3 dimensional picture of the knee joint, bilaterally. This scanner by Curve Beam 175 Titus
Ave, Suite 300, Warrington, Pennsylvania 18976, has been approved by the Food and Drug
Administration (FDA) for ankles and feet. This has been modified to do the scan of the knee
but is not yet approved by the FDA for the knees. The proposed ancillary study would add the
key benefit of providing more sensitive and accurate identification of prevalent knee
osteoarthritis (OA) at baseline and incident knee OA at follow-up than is available with
plain radiographs. In addition, it would enable biomechanical modeling of the knee joint on a
larger scale than achieved in any prior study, allowing testing of biomechanical hypotheses
regarding mechanisms of disease development and progression that have not been possible on
this scale previously.
#201511711). Using a prototype Curve Beam Standing Computed Tomography (SCT) scanner to get a
3 dimensional picture of the knee joint, bilaterally. This scanner by Curve Beam 175 Titus
Ave, Suite 300, Warrington, Pennsylvania 18976, has been approved by the Food and Drug
Administration (FDA) for ankles and feet. This has been modified to do the scan of the knee
but is not yet approved by the FDA for the knees. The proposed ancillary study would add the
key benefit of providing more sensitive and accurate identification of prevalent knee
osteoarthritis (OA) at baseline and incident knee OA at follow-up than is available with
plain radiographs. In addition, it would enable biomechanical modeling of the knee joint on a
larger scale than achieved in any prior study, allowing testing of biomechanical hypotheses
regarding mechanisms of disease development and progression that have not been possible on
this scale previously.
Inclusion Criteria:
Only participants in the Multicenter Osteoarthritis Study (MOST) who attend a 0/144-month
visit at the Iowa site are eligible for inclusion.
Additional Inclusion Criteria Include:
- Completed knee radiograph (posteroanterior view) at 0/144-month visit of primary
MOST-second renewal study at the Iowa Site
Exclusion Criteria:
- Bilateral Total Knee Arthroplasty
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University of Iowa With just over 30,000 students, the University of Iowa is one of...
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