Free Fatty Acids-Induced Hypertension in Obese Subjects (Aim #2)
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 1/10/2019 |
| Start Date: | July 2009 |
| End Date: | March 2011 |
Free Fatty Acids-Induced Hypertension, Endothelial Dysfunction, Inflammation, Insulin Resistance, and Autonomic Dysfunction in Lean and Obese Subjects (Aim #2)
The purpose of this study is to see if salsalate, an Nuclear factor-kappaB (NF-κB) mediated
inflammation inhibitor, or carvedilol, an α- and β-blocker, will protect against free fatty
acid induced hypertension, insulin resistance, endothelial dysfunction, inflammation and
oxidative stress, and autonomic dysfunction in obese normotensive subjects.
inflammation inhibitor, or carvedilol, an α- and β-blocker, will protect against free fatty
acid induced hypertension, insulin resistance, endothelial dysfunction, inflammation and
oxidative stress, and autonomic dysfunction in obese normotensive subjects.
During postprandial lipemia, dietary triglycerides transported by intestinal chylomicrons are
hydrolyzed by lipoprotein lipase lining the vascular bed, with subsequent release of FFA for
transport across the endothelium. Whether the intermittent flux of FFA has the same impact as
the i.v. lipid infusion will be examined. Decreased endothelial function has been reported
after a single or long-term dietary high fat load in normal subjects; however, others have
found no effects on brachial artery vasoreactivity. Our preliminary studies indicate that
high oral fat loads (60 g) resulted in higher FFA levels and BP changes, and reduced FMD
compared to low fat load (25 g).
hydrolyzed by lipoprotein lipase lining the vascular bed, with subsequent release of FFA for
transport across the endothelium. Whether the intermittent flux of FFA has the same impact as
the i.v. lipid infusion will be examined. Decreased endothelial function has been reported
after a single or long-term dietary high fat load in normal subjects; however, others have
found no effects on brachial artery vasoreactivity. Our preliminary studies indicate that
high oral fat loads (60 g) resulted in higher FFA levels and BP changes, and reduced FMD
compared to low fat load (25 g).
Inclusion Criteria:
- Males or females
- Obese subjects (body mass index (BMI) ≥ 30 kg/m^2)
- 18 and 65 years
- Blood pressure reading < 140/80 mm Hg and no prior history of hypertension
Exclusion Criteria:
- History of diabetes mellitus
- History of hypertension
- Fasting triglyceride levels > 250 mg/dL
- Liver disease (ALT 2.5x > upper limit of normal)
- Serum creatinine ≥1.5 mg/dL
- Smokers, drug or alcohol abuse
- Mental condition rendering the subject unable to understand the scope and possible
consequences of the study
- Female subjects who are pregnant or breast feeding
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