Role of the Gut Microbiome in Complex Regional Pain Syndrome
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Pain, Orthopedic, Psychiatric, Pain |
| Therapuetic Areas: | Musculoskeletal, Psychiatry / Psychology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/1/2019 |
| Start Date: | December 19, 2018 |
| End Date: | June 2021 |
| Contact: | Lara Crock, MD PhD |
| Email: | crockl@wustl.edu |
| Phone: | 314-546-3882 |
The objective of this prospective, observational study is to determine the association
between the composition of the gut microbiota and the severity and persistence of Complex
Regional Pain Syndrome symptoms (Study A). The objective of Study B, a longitudinal study of
microbiota biomarkers of patients with newly diagnosed CRPS is to determine if the
researchers can predict which patients are more likely to recover compared to those who do
not. A secondary objective of both studies is to examine cognitive flexibility in relation to
outcomes (study A and B).
between the composition of the gut microbiota and the severity and persistence of Complex
Regional Pain Syndrome symptoms (Study A). The objective of Study B, a longitudinal study of
microbiota biomarkers of patients with newly diagnosed CRPS is to determine if the
researchers can predict which patients are more likely to recover compared to those who do
not. A secondary objective of both studies is to examine cognitive flexibility in relation to
outcomes (study A and B).
Study A: Cross-sectional study
Inclusion criteria, cases:
- Adults over the age of 18
- Current (< 1 year duration) or former (> 1 year) diagnosis of Complex Regional Pain
Syndrome by the Budapest criteria
- English as primary language
- able to consent
Inclusion criteria, controls
- Adults over age of 18
- Cohabitant of person with current or former diagnosis of CRPS
Study B: Longitudinal Study
Inclusion criteria, cases:
- Adults over the age of 18
- Recent diagnosis (<6 months) of Complex Regional Pain Syndrome by the Budapest
criteria
- English as primary language
- able to consent
Inclusion criteria, controls
- Adults over age of 18
- Cohabitant of person with diagnosis of CRPS
Study A and B: Exclusion criteria, cases and controls:
- Unwilling to participate in the study
- Lives alone
- Current use of probiotics and unwilling to stop for 1 week prior to stool sample
- Pregnant or lactating
- Vegan diet
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Laura Crock, MD
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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