A Study to Assess the Efficacy and Safety of AXS-02 in Subjects With Knee OA Associated With Bone Marrow Lesions



Status:Active, not recruiting
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:50 - Any
Updated:1/12/2019
Start Date:March 2016
End Date:December 2020

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Trial Summary
Trial Overview
Inclusion Criteria

COAST -1: Clinical Knee Osteoarthritis Symptom Treatment 1 Study. A Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of AXS-02 (Disodium Zoledronate Tetrahydrate) Administered Orally to Subjects With Knee Osteoarthritis Associated With Bone Marrow Lesions.

This is a randomized, double-blind, placebo-controlled, 24-week study to evaluate the
efficacy and safety of AXS-02 in subjects with knee osteoarthritis associated with bone
marrow lesions.


Key Inclusion Criteria:

- Male at least 50 years of age, or postmenopausal female

- Meets the ACR clinical criteria for knee osteoarthritis

- Bone Marrow Lesion of the knee present on MRI

- Additional criteria may apply

Key Exclusion Criteria:

- Previous surgery on index knee

- Any prior use of bisphosphonates within 6 months of screening

- Additional criteria may apply
We found this trial at
55
sites
Clinical Trial Facility in North Attleboro Massachusetts
North Attleboro, Massachusetts 02760
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Achieve Clinical Research
2017 Canyon Road, Suite 41
Birmingham, Alabama 35216
(205) 757-8208
Site Overview Achieve has two clinical research sites in Birmingham, AL. Our Birmingham sites are conveniently located...
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Accord Clinical Research
3635 S. Clyde Morris Blvd
Port Orange, Florida 32129
386-760-3862
About Us Accord Clinical Research is a privately owned research facility, founded in Port Orange,...
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Port Orange, FL
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Clinical Trial Facility in Albuquerque New Mexico
Albuquerque, New Mexico
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Clinical Trial Facility in Anaheim California
Anaheim, California 92801
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Clinical Trial Facility in Austin Texas
Austin, Texas 78744
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Austin, TX
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Clinical Trial Facility in Baytown Texas
Baytown, Texas
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Clinical Trial Facility in Bellevue Washington
Bellevue, Washington 98007
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Bellevue, WA
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
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Birmingham, AL
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Clinical Trial Facility in Boston Massachusetts
Boston, Massachusetts
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Boston, MA
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Clinical Trial Facility in Boynton Beach Florida
Boynton Beach, Florida 33472
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Boynton Beach, FL
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Clinical Trial Facility in Broadmeadow New South Wales
Broadmeadow, New South Wales
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Broadmeadow,
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Clinical Trial Facility in Canoga Park California
Canoga Park, California 91306
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Canoga Park, CA
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Clinical Trial Facility in Canton Georgia
Canton, Georgia
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Canton, GA
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Clinical Trial Facility in Chandler Arizona
Chandler, Arizona 85224
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Chandler, AZ
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Clinical Trial Facility in Charlotte North Carolina
Charlotte, North Carolina 28207
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Charlotte, NC
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
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Chicago, IL
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Cincinnati, OH
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Clinical Trial Facility in Clearwater Florida
Clearwater, Florida 33756
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Clearwater, FL
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Clinical Trial Facility in Clermont Florida
Clermont, Florida 34711
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Clermont, FL
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Clinical Trial Facility in Denver Colorado
Denver, Colorado
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Denver, CO
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Clinical Trial Facility in Desoto Texas
Desoto, Texas
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Desoto, TX
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Clinical Trial Facility in Duncansville Pennsylvania
Duncansville, Pennsylvania 16635
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Clinical Trial Facility in El Cajon California
El Cajon, California 92020
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Clinical Trial Facility in Franklin Tennessee
Franklin, Tennessee 37067
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Franklin, TN
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Clinical Trial Facility in Hartsdale New York
Hartsdale, New York
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Hartsdale, NY
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Clinical Trial Facility in Hialeah Florida
Hialeah, Florida
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Hialeah, FL
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Clinical Trial Facility in Hot Springs Arkansas
Hot Springs, Arkansas 71901
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Hot Springs, AR
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Clinical Trial Facility in Jupiter Florida
Jupiter, Florida 33458
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Jupiter, FL
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Clinical Trial Facility in Kansas City Missouri
Kansas City, Missouri 64108
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Clinical Trial Facility in La Mesa California
La Mesa, California 91942
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La Mesa, CA
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Clinical Trial Facility in Lauderdale Lakes Florida
Lauderdale Lakes, Florida 33313
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Clinical Trial Facility in Long Beach California
Long Beach, California 90806
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Clinical Trial Facility in Los Angeles California
Los Angeles, California
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Clinical Trial Facility in Milford Connecticut
Milford, Connecticut 06460
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Milford, CT
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Clinical Trial Facility in Mount Pleasant South Carolina
Mount Pleasant, South Carolina 29464
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Mount Pleasant, SC
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Clinical Trial Facility in Newport News Virginia
Newport News, Virginia 23601
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Newport News, VA
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Clinical Trial Facility in Newton Kansas
Newton, Kansas
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Newton, KS
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Clinical Trial Facility in North Hollywood California
North Hollywood, California 91606
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Affinity Clinical Research Institute
Oak Lawn, Illinois 60453
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Oak Lawn, IL
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Clinical Trial Facility in Oak Lawn Illinois
Oak Lawn, Illinois 60453
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Clinical Trial Facility in Orlando Florida
Orlando, Florida 32804
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Clinical Trial Facility in Phoenix Arizona
Phoenix, Arizona
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Clinical Trial Facility in Port Saint Lucie Florida
Port Saint Lucie, Florida
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Clinical Trial Facility in Quincy Massachusetts
Quincy, Massachusetts 62301
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Quincy, MA
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Clinical Trial Facility in Raleigh North Carolina
Raleigh, North Carolina 27607
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Clinical Trial Facility in Rochester New York
Rochester, New York
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Clinical Trial Facility in Sacramento California
Sacramento, California 95825
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Clinical Trial Facility in Saint Louis Missouri
Saint Louis, Missouri 63110
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Clinical Trial Facility in San Diego California
San Diego, California
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Clinical Trial Facility in Sarasota Florida
Sarasota, Florida 34239
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Clinical Trial Facility in Thousand Oaks California
Thousand Oaks, California 91360
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Clinical Trial Facility in Upland California
Upland, California 91786
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Clinical Trial Facility in Wheaton Maryland
Wheaton, Maryland 20902
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Clinical Trial Facility in Wichita Falls Texas
Wichita Falls, Texas 76301
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