Developmental Epidemiological Study of Children Born Through Reproductive Technology
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies, Infertility |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 4 - Any |
| Updated: | 1/12/2019 |
| Start Date: | July 14, 2017 |
| End Date: | January 1, 2020 |
| Contact: | Study coordinator |
| Email: | descrt@ucsf.edu |
| Phone: | 415.476.3798 |
The Developmental Epidemiological Study of Children Born Through Reproductive Technology
DESCRT will be a long-term study that both looks back in time, at successful pregnancies, and
forward in time at early pregnancy and long-term as these children grow. Currently, there are
limited data on the long-term effects of infertility and infertility treatments on children.
There are some studies to suggest that these children may have altered metabolic profiles,
but this study aims to be the largest study to answer this question.
forward in time at early pregnancy and long-term as these children grow. Currently, there are
limited data on the long-term effects of infertility and infertility treatments on children.
There are some studies to suggest that these children may have altered metabolic profiles,
but this study aims to be the largest study to answer this question.
Over the past 30 years, much of the research and clinical effort in the field of ART had to
do with improving outcome in terms of successful pregnancy. However, as these rates have
increased, attention is slowly turning to focus on the health of the resultant child.
Short-term health complications, in particular birth defects,have been well-described.
However, even this "hard" outcome has been difficult to characterize as studies used
different methodologies, varied age of detection, and frequently didn't have an appropriate
comparison group. When underlying parental factors and infertility are included in the
analyses, the association is substantially weakened or disappears completely. This
exemplifies the problems with much of the currently available research regarding childhood
outcomes following ART. While the health of children born through these technologies is of
critical public health interest, and of personal interest to families, only limited data
exist.
In order to evaluate the potential risk to long-term health of children conceived through
assisted reproductive technologies (ART) and non-IVF fertility treatments (NIFT), rigorous
epidemiological methods, appropriate characterization of the exposure, standardized
collection of outcome data, and appropriate comparison groups are required. The proposed
Developmental Epidemiological Study of Children born through Reproductive Technology (DESCRT)
is aimed to carefully address these important characteristics.
do with improving outcome in terms of successful pregnancy. However, as these rates have
increased, attention is slowly turning to focus on the health of the resultant child.
Short-term health complications, in particular birth defects,have been well-described.
However, even this "hard" outcome has been difficult to characterize as studies used
different methodologies, varied age of detection, and frequently didn't have an appropriate
comparison group. When underlying parental factors and infertility are included in the
analyses, the association is substantially weakened or disappears completely. This
exemplifies the problems with much of the currently available research regarding childhood
outcomes following ART. While the health of children born through these technologies is of
critical public health interest, and of personal interest to families, only limited data
exist.
In order to evaluate the potential risk to long-term health of children conceived through
assisted reproductive technologies (ART) and non-IVF fertility treatments (NIFT), rigorous
epidemiological methods, appropriate characterization of the exposure, standardized
collection of outcome data, and appropriate comparison groups are required. The proposed
Developmental Epidemiological Study of Children born through Reproductive Technology (DESCRT)
is aimed to carefully address these important characteristics.
Retrospective arm
Inclusion criteria:
- children conceived by parent(s) who sought evaluation/treatment for infertility
Exclusion criteria:
- Children with chronic medical illnesses that prevent a study visit
Prospective arm
Inclusion criteria:
- seeking evaluation/treatment for infertility
Exclusion criteria:
- none
We found this trial at
1
site
San Francisco, California 94143
Principal Investigator: Marcelle I. Cedars, MD
Phone: 415-353-7475
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