Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity

Inclusion Criteria:

- Informed consent obtained before any study-related activities. Study-related
activities are any procedures that are carried out as part of the study, including
activities to determine eligibility for the study

- Male or female, age more than or equal to 18 years at the time of signing informed
consent

- Body mass index (BMI) more than or equal 30 kg/m^2

- Enrolled in Cleveland Clinic Employee Health Plan, and expecting to be covered by the
Cleveland Clinic Employee Health Plan for the duration of the study

Exclusion Criteria:

- Contraindications to all of the medications approved by the FDA for chronic weight
management according to the label

- Previous participation in this study. Participation is defined as signed informed
consent

- Female who is pregnant, breast-feeding or intends to become pregnant or is of
child-bearing potential and not using adequate contraceptive methods (adequate
contraceptive measures as required by local regulation or practice)

- Participation in another clinical trial within 30 days before screening

- Treatment with any medication with the intention of weight loss within 90 days before
screening

- Previous or current participation in Cleveland Clinic's Integrated Medical Weight
Management Program

- History of (or plans during the study period for) bariatric surgery, or use of
minimally-invasive weight loss devices (i.e. Intragastric balloons, lap bands) not
removed within 1 year prior to screening

- History of type 1 or type 2 diabetes mellitus

- Hemoglobin A1c (HbA1c) more than or equal to 6.5% at screening or within 90 days prior
to randomization

- Any condition, unwillingness or inability, not covered by any of the other exclusion
criteria, which, in the study clinician's opinion, might jeopardize the subject's
safety or compliance with the protocol