Genetic Variants in Nicotinamide Adenine Dinucleotide (NAD) Synthesis Pathway



Status:Not yet recruiting
Conditions:Women's Studies
Therapuetic Areas:Reproductive
Healthy:No
Age Range:13 - Any
Updated:1/12/2019
Start Date:January 1, 2019
End Date:January 2020

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Trial Summary
Trial Overview
Inclusion Criteria

Identifying Genetic Variants in Nicotinamide Adenine Dinucleotide (NAD) Synthesis Pathway in Patients With Congenital Malformations

Researchers are trying to identify versions of genes as well as factors in subjects blood
associated with certain types of congenital malformations(CMs). This study will help the
researchers to better understand family traits that contribute to CMs.


Inclusion Criteria:

1. Adults with confirmed or putative diagnosis of VACTERL association;

2. Families (mother, father, offspring 13 and over) with a history of VACTERL-associated
malformations

3. Gravid or non-gravid women with a history of miscarriage and/or offspring with
non-VACTERL-associated malformations

4. Willingness to abstain from red meat, meat products, chicken, peanuts, or brewer's
yeast (including beer) at least 24 hours prior to blood and urine collection

Exclusion Criteria:

1. Parents of non-biological children

2. Children under 13 years of age

3. Children (13 and over) with congenital malformations associated with an identifiable
environmental or lifestyle exposure

4. Children (13 and over) with congenital malformations associated with confirmed
chromosomal disorders

5. Failure to abstain from red meat, meat products, chicken, peanuts, or brewer's yeast
(including beer) at least 24 hours prior to blood and urine collection.
We found this trial at
1
site
The Mayo Clinic
Rochester, Minnesota 55905
?
mi
from
Rochester, MN
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