Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry

We are collecting brain tissue specimens and blood samples from patients at Vanderbilt
University Medical Center who are undergoing intracranial surgery to remove brain tissue,
including brain tumors, tissue from epilepsy surgery and brain tissue removed during surgery
for other non-cancerous types of brain tissus. These specimens will then be studied using a
novel microscopic laser-directed protein mass spectrometric analysis. Data from different
brain tissues including tumors of different histological sub-types will be analyzed for
unique protein signatures. These protein signatures will then be statistically correlated
with clinical data including time to tumor progression and response to therapy.

The goal of this study is to determine molecular patterns that will be more predictive of
tumor behavior, thus leading to an improved understanding of the basic biology of these
poorly understood cancers. This in turn, may lead to more refined therapies and improved
outcomes.

Inclusion Criteria:

- A diagnosis of brain tumor or other non-cancerous tissue and are considered candidates
fro a surgical procedure to biopsy or remove the brain tumor or other tissue type at
Vanderbilt University Medical Center.

- Age 2 to 85

Exclusion Criteria:

- Patient or guardian that is unable to understand the informed consent process.