Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee

Key Inclusion Criteria:

1. A clinical diagnosis of OA of the knee or hip based on the American College of
Rheumatology criteria with radiologic evidence of OA (K-L score ≥2 for the index
joint) at the screening visit

2. Moderate-to-severe pain in the index joint defined as a WOMAC average pain subscale
score of ≥4 at both the screening and randomization visits

3. Willing to discontinue current pain medications and to adhere to study requirements
for rescue treatments

4. A history of regular use of analgesic medications for OA pain (defined as an average
of 4 days per week over the 4 weeks prior to the screening visit), including oral
nonsteroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase 2 inhibitors,
opioids, paracetamol/acetaminophen, or combinations thereof

5. Consent to allow all radiographs and medical/surgical/hospitalization records of care
received elsewhere prior to and during the study period to be shared with the
investigator

Key Exclusion Criteria:

1. History or presence at the screening visit of non-OA inflammatory joint disease (eg,
rheumatoid arthritis, lupus erythematosus, psoriatic arthritis, pseudo-gout, gout,
spondyloarthropathy, polymyalgia rheumatica, joint infections within the past 5
years), Paget's disease of the spine, pelvis or femur, neuropathic disorders, multiple
sclerosis, fibromyalgia, tumors or infections of the spinal cord, or renal
osteodystrophy

2. History or presence on imaging of arthropathy (osteonecrosis, subchondral
insufficiency fracture, rapidly progressive OA type 1 or type 2), stress fracture,
recent stress fracture, neuropathic joint arthropathy, hip dislocation (prosthetic hip
dislocation is eligible), knee dislocation (patella dislocation is eligible),
congenital hip dysplasia with degenerative joint disease, extensive subchondral cysts,
evidence of bone fragmentation or collapse, or primary metastatic tumor with the
exception of chondromas or pathologic fractures during the screening period

3. Trauma to the index joint within 3 months prior to the screening visit

4. History or presence of signs or symptoms of compression neuropathy, including carpal
tunnel syndrome or sciatica

5. Participant is not a candidate for Magnetic Resonance Imaging (MRI)

6. Poorly controlled diabetes

7. Known history of human immunodeficiency virus (HIV) infection

8. Known history of ocular herpes simplex virus, herpes simplex virus pneumonia, or
herpes simplex virus encephalitis

9. History of poorly controlled hypertension

10. Known history of infection with hepatitis B or C virus

Note: Other protocol defined Inclusion/Exclusion apply