Sleep Disordered Breathing in Acute Congestive Heart Failure

Consecutive patients admitted to the hospital with acutely decompensated heart failure will
be identified for potential enrollment in this study. Enrolled patients will first be asked
to complete questionnaires to assess their symptoms and risk of having sleep apnea.

Relevant information will be obtained from the electronic medical record (age, gender, body
mass index, co-morbidities, medications, prior echocardiography results). Subjects will then
undergo a "type III" portable monitoring sleep study on the first or second night of their
hospital admission, which measures respiratory effort, nasal airflow, oxyhemoglobin
saturation, and heart rate. Blood samples will be collected on the evening before (08:00 PM
+/- 2 hours), and the morning after (06:00 AM +/-2 hours) sleep apnea testing. If not
otherwise obtained clinically, echocardiography will be obtained within 48 hours of
admission. After a period of medical management for acutely decompensated heart failure,
subjects will then have a second portable sleep apnea study (with associated pre and
post-sleep blood draws) on the evening prior to discharge (approximately hospital day 5 or
6). Later, clinical outcomes such as incidence of renal dysfunction, hospital length of stay
etc. will be collected from the electronic medical record. Blood samples will be processed,
stored, and subsequently analyzed for high-sensitivity cardiac troponin T and I.

Inclusion Criteria:

- Patients age 18-80 years admitted to University of California San Diego La Jolla
campus (Sulpizio Cardiovascular Center, Jacobs Medical Center, and Thornton Hospital)
with acute decompensated heart failure will be identified in the emergency department,
or upon admission to the cardiology or inpatient general medical services.

Exclusion Criteria:

- Known diagnosis of sleep disordered breathing and on treatment while hospitalized.

- Suspected acute coronary syndrome as determined by the primary clinical team.

- Intensive care unit level care.

- Requiring advanced heart failure therapy such as inotrope infusion, mechanical
circulatory support etc.

- Intolerance of study procedures.

- Clinical attending physician refusal