Thyroid Function of Pediatric Subjects Following Isovue® Administration

Inclusion Criteria:

- Is male or female from 0 to 3 years of age;

- Is scheduled to undergo a radiologic examination that requires intravascular
administration of ISOVUE as part of his/her standard of care;

- Has normal baseline thyroid function tests (TSH, total T3, total T4, and fT4)
performed at a local laboratory with blood sample obtained within one week prior to
ISOVUE administration;

- Written informed consent is obtained from the subject's parent(s) or legally
acceptable representative(s) (according to local regulations) who are willing to
comply with the protocol requirements.

Exclusion Criteria:

- Has any known allergy to one or more of the ingredients of ISOVUE;

- Has been diagnosed with congenital hypothyroidism;

- Has undergone radiation treatments to the head or neck;

- Is currently on thyroid replacement therapy;

- Is on therapy with dopamine or any treatment which may affect the thyroid function
testing results;

- Has been exposed to any topical iodinated product within 30 days prior to enrollment
in the present study;

- Has been exposed to an iodinated contrast agent within 1 year prior to enrollment in
the present study, including any administration of iodinated contrast agents during
placement of a central line;

- Has any medical condition or other circumstances which would significantly decrease
the chances of obtaining reliable data, achieving study objectives, or completing the
study and/or post-dose follow-up examinations.