A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning



Status:Not yet recruiting
Healthy:No
Age Range:19 - 60
Updated:3/30/2019
Start Date:September 30, 2019
End Date:January 1, 2022
Contact:Jonathan McConathy, MD, PhD
Email:jmcconathy@uabmc.edu
Phone:205-934-6504

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Trial Summary
Trial Overview
Inclusion Criteria
The overall aim of this project is to implement a non-invasive method of measuring
quantitative regional cerebral blood flow (rCBF) on the UAB hybrid PET/MRI scanner to allow
conducting such [O-15]water based scans with relative ease and safety in a large variety of
important clinical and research applications. Participants will undergo imaging at baseline
and after administration of a drug to increase cerebral blood flow to evaluate perfusion
estimates during low and high flow states. The goal of this study is to generate data that
will justify eliminating invasive arterial sampling in most [O-15]water-based PET protocols.


Inclusion Criteria:

- Six participants aged 19-60 years of age, male and female, with no evidence of
neurological disease, will be recruited from UAB and the surrounding community.

Exclusion Criteria:

- Participants will be excluded if there is any evidence or history of claustrophobia or
the subject has metallic implants or devices that are normally exclusion factors for
MRI.
We found this trial at
2
sites
Kirklin Clinic
Birmingham, Alabama 35233
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Birmingham, AL
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UAB Advanced Imaging Facility
619 19th Street South
Birmingham, Alabama 35294
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Birmingham, AL
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