An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA
| Status: | Recruiting |
|---|---|
| Conditions: | Osteoarthritis (OA), Hospital |
| Therapuetic Areas: | Rheumatology, Other |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 1/26/2019 |
| Start Date: | January 1, 2017 |
| End Date: | December 31, 2022 |
| Contact: | Catherine Fruehling, BA |
| Email: | catherine-fruehling@uiowa.edu |
| Phone: | 3194678256 |
The immediate goal of the proposed research is to test the value of a new low-cost, low-dose
standing CT system for efficient early detection of both joint degeneration and elevated
contact stress. The standing CT scanner holds promise for detecting arthritic changes earlier
than other imaging modalities because of the combination of its 3D nature and ability to
image joints in a weight-bearing pose. A secondary goal of the proposed research is to enable
predictive models for osteoarthritis risk based on measures of post treatment contact stress,
both to inform treatment and so that new interventions can be tested in a manner
incorporating risk stratification.
standing CT system for efficient early detection of both joint degeneration and elevated
contact stress. The standing CT scanner holds promise for detecting arthritic changes earlier
than other imaging modalities because of the combination of its 3D nature and ability to
image joints in a weight-bearing pose. A secondary goal of the proposed research is to enable
predictive models for osteoarthritis risk based on measures of post treatment contact stress,
both to inform treatment and so that new interventions can be tested in a manner
incorporating risk stratification.
Individuals who present with an intra-articular of the tibial plafond will be consented to
participate in this study. We will obtain pedCAT scans at 6, 12, and 18 months post-injury,
as well as several questionnaires that will be administered during the clinical visits. We
will also review the subjects' electronic medical record for data related to the injury,
including the timing and mechanism of injury, time from injury to surgery, length of hospital
stay, any complications and/or subsequent ankle surgeries, as well as any clinic notes,
imaging, and/or outcomes scores related to the calcaneus fracture.
participate in this study. We will obtain pedCAT scans at 6, 12, and 18 months post-injury,
as well as several questionnaires that will be administered during the clinical visits. We
will also review the subjects' electronic medical record for data related to the injury,
including the timing and mechanism of injury, time from injury to surgery, length of hospital
stay, any complications and/or subsequent ankle surgeries, as well as any clinic notes,
imaging, and/or outcomes scores related to the calcaneus fracture.
Inclusion Criteria:
- Individuals 18 to 70 years old Sustained an intra-articular fracture of the tibial
plafond Indicated for operative treatment Present for treatment within 4 weeks of
injury
Exclusion Criteria:
- Women who are pregnant or planning on becoming pregnant Individuals younger than 18
and older than 70
We found this trial at
1
site
200 Hawkins Dr,
Iowa City, Iowa 52242
Iowa City, Iowa 52242
866-452-8507
Principal Investigator: J L Marsh, MD
Phone: 319-467-8256
University of Iowa Hospitals and Clinics University of Iowa Hospitals and Clinics—recognized as one of...
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