Mindfulness Based Cognitive Therapy (MBCT) During Pregnancy

The study will involve an online screen of potentially eligible pregnant women. If
participants are eligible after the online screen, they will be invited in for an in person
assessment, including cognitive testing and a diagnostic interview, to determine eligibility.
After the assessment, they will be informed of their eligibility status and, if applicable,
randomized to Mindfulness Based Cognitive Therapy (MBCT) or treatment as usual (TAU).
Participants in the MBCT group will complete 8 weekly, 2 hr group therapy sessions during
pregnancy, as well as receive TAU. The TAU group will engage in regular care during pregnancy
and be offered the option to attend one mindfulness psychoeducation session postpartum.
Participants in the MBCT group will complete questionnaires prior to the 1st group session,
after the 4th session, and after the 8th/final session. Participants in the TAU group will
complete the same questionnaires at equivalent time points. All participants will come in for
an in-person session at 34 weeks GA, during which they will complete questionnaires and a
brief clinical interview. Participants will come in for an MRI scan session at 6 weeks
postpartum. In addition to structural and functional MRI scanning, they will also complete
questionnaires, a cognitive task, and brief psychiatric interview. At 6 months postpartum,
participants will return for a visit, during which they will complete questionnaires,
cognitive measures, and a clinical interview. This will be the final visit for women in the
MBCT group. Women in the TAU group will complete a singe mindfulness psychoeducation session
between 6 and 9 months postpartum; this must occur after their 6 month visit.

Inclusion:

1. female who is currently pregnant (8-18 weeks gestational age (GA) at time of screen)

2. 21-45 years old

3. primiparous

4. single gestation

5. fluently speak English

6. be available and physically able to attend scheduled group meetings

7. have a prior history of at least 1 major depressive episode (as determined through
psychiatric interviewing).

Exclusion (at enrollment):

1. Magnetic Resonance Imaging (MRI) contraindication (e.g., metal in their body, pregnant
or suspect they could be pregnant on the day of the scan)

2. major neurological or medical illness (e.g., diabetes, multiple sclerosis)

3. history of head trauma (loss of conscious > 2 minutes)

4. Intelligence Quotient (IQ) < 80

5. uncorrectable vision or hearing impairments (including color blindness)

6. use of psychotropic medications, corticosteroids, insulin, or any other medications
that might impact the central nervous system

7. current illicit drug use or diagnosis of a substance use disorder

8. current diagnosis of an eating disorder

9. current depressive or manic episode

10. diagnosis of a neurodevelopmental disorder

11. any history of psychosis

12. current: active suicidality and/or homicidality, or interpersonal violence

13. prior history of engaging in mindfulness-based psychotherapeutic interventions (e.g.,
Mindfulness Based Cognitive Therapy (MBCT), Mindfulness Based Stress Reduction (MBSR),
Dialectical Behavior Therapy (DBT))

14. known congenital, genetic, or neurologic disorder of the fetus (e.g., Down syndrome,
fragile X)

15. pregnancy-specific medical conditions or complications that significantly increase
risk (e.g., placental separation, placenta previa)