Potatoes, Hypertension RIsk and Endothelial Function Study
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 1/23/2019 |
| Start Date: | February 15, 2018 |
| End Date: | January 2021 |
| Contact: | Ryan Jones |
| Email: | BWHPHRIES@partners.org |
| Phone: | 617-525-7638 |
White potatoes have recently been allowed back in the cash value voucher of the government
food stamp program after it was stated that there were no known adverse health effects of
potatoes. However, the association of potatoes with heart health, especially elevated blood
pressure is not known. This study will examine the effects of potatoes on blood pressure in
different populations of adults and children, and assess, in a feeding trial, the effects of
an additional serving of potatoes per day on the possible mechanisms that link potatoes to
high blood pressure. The investigators will also analyze the intake of potatoes in
participants of the government food stamp program.
food stamp program after it was stated that there were no known adverse health effects of
potatoes. However, the association of potatoes with heart health, especially elevated blood
pressure is not known. This study will examine the effects of potatoes on blood pressure in
different populations of adults and children, and assess, in a feeding trial, the effects of
an additional serving of potatoes per day on the possible mechanisms that link potatoes to
high blood pressure. The investigators will also analyze the intake of potatoes in
participants of the government food stamp program.
Potatoes are one of the most consumed vegetables in the US and the world. In recent years,
several changes have been made to government sponsored food programs with respect to
potatoes, such as lifting the restriction on the number of servings of starchy vegetables
(including potatoes) established by the Healthy Hunger-Free Act, and re-allowing white
potatoes in the cash-value voucher for fruits and vegetables of the Special Supplemental
Nutrition Program for Women, Infants, and Children (WIC), after the Institute of Medicine
asserted that there was insufficient evidence that white potatoes had adverse health effects.
However, the investigators recently reported an increased incidence of hypertension with
increasing potato consumption in three large prospective US cohort studies after adjusting
for sodium intake and other potential confounders. The investigators also analyzed the
association of short-term potato intake from a 24-hr dietary recall with
endothelial-dependent vasodilation measured by brachial artery ultrasonography in the
Modifiable Effectors of Renin System Activation Treatment Evaluation (MODERATE) trial.
Participants who consumed one or more than one serving of boiled, baked or mashed potatoes
during the previous day had a 1.7% lower endothelial-dependent vasodilation when compared
with participants with no potato intake (p-value= 0.01) after adjusting for other factors.
This is a relevant difference in endothelial function - by comparison, every 10 year increase
in age was associated with a 1.2% lower endothelial function. Therefore, the investigators
plan to analyze the effect of one serving of boiled, baked or mashed potato per day on
endothelial function in a crossover feeding trial of healthy adult men and women.
several changes have been made to government sponsored food programs with respect to
potatoes, such as lifting the restriction on the number of servings of starchy vegetables
(including potatoes) established by the Healthy Hunger-Free Act, and re-allowing white
potatoes in the cash-value voucher for fruits and vegetables of the Special Supplemental
Nutrition Program for Women, Infants, and Children (WIC), after the Institute of Medicine
asserted that there was insufficient evidence that white potatoes had adverse health effects.
However, the investigators recently reported an increased incidence of hypertension with
increasing potato consumption in three large prospective US cohort studies after adjusting
for sodium intake and other potential confounders. The investigators also analyzed the
association of short-term potato intake from a 24-hr dietary recall with
endothelial-dependent vasodilation measured by brachial artery ultrasonography in the
Modifiable Effectors of Renin System Activation Treatment Evaluation (MODERATE) trial.
Participants who consumed one or more than one serving of boiled, baked or mashed potatoes
during the previous day had a 1.7% lower endothelial-dependent vasodilation when compared
with participants with no potato intake (p-value= 0.01) after adjusting for other factors.
This is a relevant difference in endothelial function - by comparison, every 10 year increase
in age was associated with a 1.2% lower endothelial function. Therefore, the investigators
plan to analyze the effect of one serving of boiled, baked or mashed potato per day on
endothelial function in a crossover feeding trial of healthy adult men and women.
Inclusion Criteria:
- 18-45 years of age
- without known cardiovascular risk factor
Exclusion Criteria:
- History of hypertension, diabetes or cardiovascular disease
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