Physiology, Imaging and Modeling of Essential Tremor
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Parkinsons Disease, Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 2/8/2019 |
| Start Date: | March 2019 |
| End Date: | April 2020 |
| Contact: | Leonardo B Almeida, MD |
| Email: | Leonardo.BritodeAlmeida@neurology.ufl.edu |
| Phone: | (352) 294-5400 |
Physiology, Imaging and Modeling of Deep Brain Stimulation for Essential Tremor
This project aims to investigate novel ways to deliver brain stimulation to Essential Tremor
(ET) patients by introducing software changes to their existing devices. The study team aims
to investigate safety and efficacy of these new stimulation parameters in patients with ET.
(ET) patients by introducing software changes to their existing devices. The study team aims
to investigate safety and efficacy of these new stimulation parameters in patients with ET.
Deep brain stimulation (DBS) is a neuromodulatory therapy that is effective in a subset of
well selected essential tremor (ET) patients. However, as many as 1/5 of patients may
initially improve, but then steadily worsen following the operation. The investigators
developed a technique to study a variety of alternative stimulation methods without the use
of an invasive repeat surgical intervention.
The electrophysiological effects of non-conventional DBS differ from traditional DBS, however
the physiological differences in the setting of human tremor remain largely unknown. This
study plans to explore gaps in knowledge of neuromodulation and will collect and contribute
essential information to the underlying mechanism of action of DBS. The hypothesis of this
project centers around active biphasic stimulation providing a wider therapeutic window and a
lower adverse event profile as compared to conventional DBS.
well selected essential tremor (ET) patients. However, as many as 1/5 of patients may
initially improve, but then steadily worsen following the operation. The investigators
developed a technique to study a variety of alternative stimulation methods without the use
of an invasive repeat surgical intervention.
The electrophysiological effects of non-conventional DBS differ from traditional DBS, however
the physiological differences in the setting of human tremor remain largely unknown. This
study plans to explore gaps in knowledge of neuromodulation and will collect and contribute
essential information to the underlying mechanism of action of DBS. The hypothesis of this
project centers around active biphasic stimulation providing a wider therapeutic window and a
lower adverse event profile as compared to conventional DBS.
Inclusion Criteria:
- Existing unilateral or bilateral VIN DBS for ET, non-demented (MMSE>24), and must have
a documented suboptimal tremor suppression on two successive visits (compared to the
baseline post-operative improvement at 6 months following ET DBS surgery). For
bilateral cases, the most affected tremor side will be studied.
Exclusion Criteria:
- No diagnosis of Essential Tremor
We found this trial at
2
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