IPG Replacement Study (PREFERENCE-H)

Inclusion Criteria:

- Subject signed the approved Informed Consent;

- Subject is ≥18 and ≤ 74 years of age;

- Subject is bilaterally treated with deep brain stimulation (DBS) in the subthalamic
nucleus (STN) using a constant voltage device (i.e. Soletra™, Itrel™, Kinetra™,
ActivaPC™ or ActivaRC™ IPG) and in the Investigator's opinion, is responding
satisfactory to CV stimulation;

- In the physician's opinion the subject is a suitable candidate for an IPG replacement
with different stimulation paradigm;

- Subject needs and/or requests an IPG replacement within 12 months after consent and
the current IPG has at least 2.6 V output left (i.e. approx. 30% of full battery
capacity) at the time of subject enrollment;

- PD symptom onset is no longer than 20 years;

- Subject has a Hoehn & Yahr score
- Subject with a normal cognitive function (MMSE ≥ 25);

- Subject is fluent speaker (as judged by the investigator) of the language spoken in
the country where the investigational site is located.

Exclusion Criteria:

- IPG battery has less than 30% battery life at the time of consent;

- Need to replace or reposition the leads or extensions during the IPG replacement
procedure;

- Subject had >10 recurrent falls experienced in the 3 months prior to consent;

- Subject is unwilling to change to either a St Jude Medical InfinityTM or a St Jude
Medical BrioTM DBS system for the IPG replacement;

- Subject is unable to attend the study visits.