The Sleep Amyloid, Slow WAve Race and Ethnicity Study
| Status: | Recruiting |
|---|---|
| Conditions: | Alzheimer Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 60 - 75 |
| Updated: | 3/16/2019 |
| Start Date: | November 21, 2018 |
| End Date: | June 2023 |
| Contact: | Eirene Oji |
| Email: | eirene.oji@nyulangone.org |
| Phone: | 2122635053 |
A Single-center, Observational, Longitudinal Study on the Effect of Slow Wave Sleep (SWS) Characteristics and Race and Ethnicity on Amyloid Burden (a Marker of Alzheimer's Disease Risk), Among Cognitively Normal Elderly
African-Americans (AAs) have an increased prevalence of both Alzheimer's disease (AD) and
vascular risk factors for AD such as diabetes and hypertension when compared to whites.
However, in a recent community based study of non-demented elderly, black race was associated
with higher amyloid burden after adjusting for vascular risk factors, suggesting the presence
of additional physiological differences on AD-risk by race in the early stages of the
disease. The purpose of this study is to test whether poor slow wave sleep (SWS) quantity
(SWS duration) and quality (slow wave activity, SWA) is one of these physiological factors.
To test these hypotheses, the investigators will perform community outreach in churches and
community-based organizations in Brooklyn and other NYC boroughs with which we have created
substantial ties in recent years. In consultation with community stakeholders, the
investigators will recruit 150 cognitively normal AA elderly (age 60-75) and 60 age, sex,
BMI, income and education matched non-Hispanic whites from the same geographical areas.
Investigators will first perform a medical and cognitive evaluation (Visit 1). Participants
will then undergo 2 nights of home sleep monitoring using an unattended device to exclude
OSA, followed by 7 days of actigraphy with a sleep log to record sleep duration. Both devices
will be returned by mail. Subjects with reported total sleep time (TST) between 5 and 10
hours and absence of moderate to severe OSA will be invited to perform a 2-night nocturnal
polysomnography (NPSG) (Nights 1-2) and a PiB-PET MR scan (Visit 2).
vascular risk factors for AD such as diabetes and hypertension when compared to whites.
However, in a recent community based study of non-demented elderly, black race was associated
with higher amyloid burden after adjusting for vascular risk factors, suggesting the presence
of additional physiological differences on AD-risk by race in the early stages of the
disease. The purpose of this study is to test whether poor slow wave sleep (SWS) quantity
(SWS duration) and quality (slow wave activity, SWA) is one of these physiological factors.
To test these hypotheses, the investigators will perform community outreach in churches and
community-based organizations in Brooklyn and other NYC boroughs with which we have created
substantial ties in recent years. In consultation with community stakeholders, the
investigators will recruit 150 cognitively normal AA elderly (age 60-75) and 60 age, sex,
BMI, income and education matched non-Hispanic whites from the same geographical areas.
Investigators will first perform a medical and cognitive evaluation (Visit 1). Participants
will then undergo 2 nights of home sleep monitoring using an unattended device to exclude
OSA, followed by 7 days of actigraphy with a sleep log to record sleep duration. Both devices
will be returned by mail. Subjects with reported total sleep time (TST) between 5 and 10
hours and absence of moderate to severe OSA will be invited to perform a 2-night nocturnal
polysomnography (NPSG) (Nights 1-2) and a PiB-PET MR scan (Visit 2).
Inclusion Criteria:
- Male and female subjects with normal cognition and ages 60 to 75.
- Within normal limits on neurological and psychiatric examinations. All subjects
enrolled will have a CDR=0.
- An informed family member or life-partner (preferably bed-partner) will be interviewed
over the phone or on the first or second visit to confirm the reliability of the
subject interview. A study partner is preferably a spouse, close friend, or relative.
- Self-identified as African-American Black or non-Hispanic white.
- All subjects must sign the Alzheimer's Disease Center consent form
Exclusion Criteria:
- History of brain tumor, MRI evidence of brain damage or brain disease including
significant trauma, hydrocephalus, seizures, mental retardation or other serious
neurological disorder (e.g. Parkinson's disease or other movement disorders).
- Significant history of alcoholism based off of the CAGE questionnaire (>2) or drug
abuse.
- History of psychiatric illness (e.g., schizophrenia, bipolar or PTSD)
- Lifelong depression and anxiety will be allowed as long as there has been no active
depressive episode within the last two years.
- Geriatric Depression Scale (short form)>6.
- Insulin dependent diabetes.
- Evidence of clinically relevant cardiac, pulmonary, endocrine or hematological
conditions based off of the PI's discretion.
- Physical impairment of such severity as to adversely affect the validity of
psychological testing.
- Any prosthetic devices (e.g., pacemaker or surgical clips) that constitutes a hazard
for MRI imaging.
- Medications affecting cognition or SWS:
- Narcotic analgesics.
- Chronic use of medications with anticholinergic activity.
- Anti-Parkinsonian medications (carbidopa/levodopa, amantadine, bromocriptine,
pergolide, selegiline).
- Others: amphetamines, amphetamine-like compounds, appetite suppressants,
phenothiazines, reserpine, buspirone, clonidine, disulfiram, guanethidine, MAO
inhibitors, theophylline, tricyclic antidepressants, gabapentin, pregabalin,
trazodone, cholinesterase inhibitors, memantine.
- Chronic use of antidepressants are allowed.
- History of a first-degree family member with early onset (age <60 years) dementia.
- Short sleepers (< 5 hours a day) and long sleepers (> 10 hours a day).
- OSA (defined as AHI4%>15 and AHI4%>5 with Epworth≥10)
- Self-identified as US-born Caribbean Black, Caribbean-born Black or African-born
Black.
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