Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 10 - 21 |
| Updated: | 1/31/2019 |
| Start Date: | February 23, 2017 |
| End Date: | September 30, 2018 |
During major surgical procedures, intravascular volume is maintained with the administration
of isotonic fluids such as Lactated Ringers (LR), Normal Saline (NS) or Normosol-R. All three
of these fluids are in common clinical use for this purpose. As large volumes of NS may
result in a dilutional acidosis and an increasing base deficit, it may cloud clinical
decision making when resuscitative efforts are guided by acid-base status on routine arterial
blood gas analysis. This is a prospective, randomized study to evaluate changes in acid-base
and electrolyte (sodium, potassium, calcium) status with the use of various isotonic fluids
for intraoperative resuscitation.
of isotonic fluids such as Lactated Ringers (LR), Normal Saline (NS) or Normosol-R. All three
of these fluids are in common clinical use for this purpose. As large volumes of NS may
result in a dilutional acidosis and an increasing base deficit, it may cloud clinical
decision making when resuscitative efforts are guided by acid-base status on routine arterial
blood gas analysis. This is a prospective, randomized study to evaluate changes in acid-base
and electrolyte (sodium, potassium, calcium) status with the use of various isotonic fluids
for intraoperative resuscitation.
Inclusion Criteria:
- Major surgical procedure requiring arterial access
Exclusion Criteria:
- Comorbid disease process that contraindicates the use of any 1 of the 3 crystalloid
solutions.
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