Head Pulse for Ischemic Stroke Detection
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/3/2019 |
| Start Date: | August 1, 2017 |
| End Date: | December 2019 |
| Contact: | Dominca Randazzo |
| Email: | dominica.randazzo@ucsf.edu |
| Phone: | 415-206-8094 |
Measuring Cardiac Head Impulse to Detect Acute Large Vessel Ischemic Stroke
Accurate diagnosis of stroke due to large vessel occlusion (LVO) is an essential step in
providing acute stroke care to a community. The gold-standard for diagnosis LVO is brain
imaging, which is impractical in the pre-hospital setting. A non-invasive method to detect
LVO is needed. Using highly sensitive accelerometers, one can measure the "HeadPulse"- tiny
forces exerted on the skull from the cardiac contraction. This study tests the hypothesis
that LVO alters the HeadPulse characteristically. Analysis of these data along with the
subjects vascular status (LVO vs. non-LVO as measured by CT angiography) will be used to
create a model that can predict LVO status in suspect stroke subjects.
providing acute stroke care to a community. The gold-standard for diagnosis LVO is brain
imaging, which is impractical in the pre-hospital setting. A non-invasive method to detect
LVO is needed. Using highly sensitive accelerometers, one can measure the "HeadPulse"- tiny
forces exerted on the skull from the cardiac contraction. This study tests the hypothesis
that LVO alters the HeadPulse characteristically. Analysis of these data along with the
subjects vascular status (LVO vs. non-LVO as measured by CT angiography) will be used to
create a model that can predict LVO status in suspect stroke subjects.
Large vessel occlusion (LVO) ischemic stroke is a treatable disease at specialized centers.
Clinical outcomes of patients with LVO is time-dependent. To maximize clinical benefit of
thrombectomy, stroke systems of care need accurate methods to triage patients with LVO to
comprehensive stroke centers or thrombectomy ready centers rather than closer primary stroke
centers.
EPISODE will evaluate whether measurements of the HeadPulse can predict the presence or
absence of LVO based on recordings from a consecutive series of patients undergoing CTA for
suspected stroke. Recordings from patients pre- and post-thrombectomy will also be compared
to investigate whether a systematic change in cranial forces exists during LVO.
Clinical outcomes of patients with LVO is time-dependent. To maximize clinical benefit of
thrombectomy, stroke systems of care need accurate methods to triage patients with LVO to
comprehensive stroke centers or thrombectomy ready centers rather than closer primary stroke
centers.
EPISODE will evaluate whether measurements of the HeadPulse can predict the presence or
absence of LVO based on recordings from a consecutive series of patients undergoing CTA for
suspected stroke. Recordings from patients pre- and post-thrombectomy will also be compared
to investigate whether a systematic change in cranial forces exists during LVO.
Inclusion Criteria:
- Suspected acute stroke
- CTA or MRA performed
Exclusion Criteria:
- Any patient in whom obtaining a non-invasive recording is judged by the treating team
to interfere with clinical assessment or treatment of the patient.
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