Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease

Inclusion Criteria:

- Capable of giving verbal and signed informed consent, which includes compliance with
the requirements and restrictions listed in the ICF and in this protocol

- Have not worn contact lenses for at least 7 days prior to the screening visit and are
willing to forego the use of contact lenses for the duration of the study

- The participant should be literate, able to speak English, and able to complete
questionnaires independently

Exclusion Criteria:

- Chronic or recurrent epistaxis, coagulation disorders or other conditions that, in the
opinion of the investigator, may lead to clinically significant increased bleeding

- Nasal or sinus surgery (including history of application of nasal cautery) or
significant trauma to these areas

- Cardiac demand pacemaker, implanted defibrillator or other implanted electronic device

- Corneal transplant in either or both eyes

- Current enrollment in an investigational drug or device study or participation in such
a study within 30 days of entry into this study

- Women who are pregnant, planning a pregnancy, or nursing throughout the study