Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Inclusion Criteria:

- Males or females age > 120 days and < 22 years at any participating site

- Have at least one of the following conditions associated with a known high incidence
of IMI: hematopoietic stem cell transplantation (HSCT), aplastic anemia, or
hematologic malignancy

- New (last 96 hours) radiographic evidence showing at least one pulmonary nodule ≥ 1 cm
in diameter

- Prolonged neutropenia (absolute neutrophil count < 500 cells/µl for a period of ≥ 5
consecutive days) in 30 days prior to qualifying chest MRI or CT scan date OR
currently receiving systemic therapy for acute or chronic graft-versus-host disease
(GVHD) on the date of the qualifying chest MRI or CT scan

- Subject consent or parental/guardian permission (informed consent) and if appropriate,
child assent

Exclusion Criteria:

- Weight <3 kg, so as to not exceed 3 ml/kg in a single blood draw

- Previous inclusion in this study