Dynamic Substrate Mapping (DSM) for Ischemic VT

Status:	Terminated
Conditions:	Peripheral Vascular Disease, Cardiology
Therapuetic Areas:	Cardiology / Vascular Diseases
Healthy:	No
Age Range:	18 - 80
Updated:	2/6/2019
Start Date:	July 2007
End Date:	April 2009

Clinical Feasibility of Using Dynamic Substrate Mapping to Guide Ablation of Ischemic Ventricular Tachycardia

This is a prospective, non-randomized study to determine the feasibility of using a new
technique called Dynamic Substrate Mapping (DSM) to help guide the treatment of ischemic
ventricular tachycardia (IVT). We hypothesize that DSM will lead to simpler, more effective
ablation of IVT. Results from this study will be used to determine if further clinical
investigation is warranted.

Inclusion Criteria:

- Have an ICD or CRT-D device

- Had at least 3 documented device therapies to treat VT over last 3 months

- Clinical VT is confirmed or suspected to be of ischemic origin

- Scheduled for VT ablation procedure

- LVEF > or = 20%

Exclusion Criteria:

- Inadequate AAD washout (amiodarone should be maintained at current dose)

- Unstable angina

- Active ischemia

- Cardiac surgery within prior 2 months

- Evidence of infection

- Prosthetic mitral or aortic valve or mitral/aortic valvular heart disease requiring
surgical intervention

- History of embolic event

- Myocardial infarction within prior 6 weeks

- Enrolled in another study

- Recurrent sepsis or otherwise not a candidate for catheterization

- Hypercoagulable state or inability to tolerate heparin therapy during procedure

- Has had an atriotomy or ventriculotomy within prior 4 months

- Life expectancy < 6 months

- Class IV NYHA classification

We found this trial at

sites

Hospital of the University of Pennsylvania

3400 Spruce St
Philadelphia, Pennsylvania 19104

(215) 662-4000