LoveYourBrain Yoga for Multiple Sclerosis

This study will recruit 20 subjects with multiple sclerosis (MS) to participate in a 6-week
yoga/meditation program. Subjects will be randomly assigned to one of two groups. The first
group will complete the yoga/meditation classes, followed by a waiting period. The second
group will go through a waiting period, followed by yoga/meditation classes. Two subjects
assigned to classes during the first session will be selected to participate in an MRI
sub-study to look for biomarkers of MS-associated fatigue. All subjects will complete
quesitonnaires and assessments during 3 clinic visits - at baseline, in between the class
sessions, and at the end of the study. Questionnaires will also be mailed to subjects 6 weeks
after the last study visit.

Inclusion Criteria:

1. Diagnosis of Multiple Sclerosis with EDSS score equal to or less than 6 (within last
year)

2. 18 years of age or older

3. Ability to ambulate without assistance from a device or person

4. Subjects taking medications for depression, fatigue, or anxiety must be stable for 8
weeks prior to baseline

5. Able to read, write, and speak English

6. Willing to refrain from participating in yoga or meditation outside of the study for
the duration of enrollment

7. Willing and able to give informed consent

Exclusion Criteria:

1. Participation in yoga and/or meditation more than twice within 8 weeks prior to
baseline.

2. MS symptom exacerbation in the 8 weeks before baseline or other serious medical
conditions that would impair ability to participate in the study.

3. Any other reason that, in the investigator's opinion, would exclude the subject from
participation in the study.

4. Contraindication to scanning, including but not limited to ferromagnetic metal in the
body, claustrophobia, inability to lie still or otherwise tolerate being in the
scanner.

5. Pregnant women must be excluded from the imaging component of the study due to unknown
but possible risk of fetal exposure to the scanner. Women of child-bearing potential
will take a confidential pregnancy test immediately prior to each scan session.