Personalized Molecular Profiling in Cancer Treatment at Johns Hopkins

The goal of this research study is to determine if we can obtain personalized genetic
information from a subject's blood sample that is similar to that obtained from a tumor
tissue sample, and if we can use that information to make treatment suggestions. As tumor
samples can be difficult to collect, we hope to be able to collect similar genetic
information from blood or urine samples that we find in tumor tissue. Ultimately, we hope to
identify genes important to cancer cells that could potentially identify standard-of-care or
research-based recommendations for therapy.

Inclusion Criteria:

- Male or Female

- 18 years of age or older

- Metastatic breast cancer and treatment with prior chemotherapy

- Any clinical phenotype (Triple negative, Hormone receptor positive, human epidermal
growth factor receptor 2 (HER2)-positive)

- Patient must have received a metastatic tumor biopsy within 1 year prior to the date
of the first planned blood sample for the study and have tissue available from this
biopsy

- Able to voluntarily provide informed consent

Exclusion Criteria:

- Women who are pregnant or nursing