Tetrahydrocannabinol (THC) and Sleep

The investigators plan to test the effects of 20-30 mg dronabinol (oral THC) on subjective
(surveys) and objective (polysomnographically scored (PSG)) sleep in non-frequent and
frequent cannabis users following an acclimation and baseline night of sleep. The mornings
after baseline sleep and dronabinol administration, cognitive performance will also be
measured and participants may also perform morning typical behaviors such as change in
posture (getting out of bed/tilt test) and mild intensity physical activity. This pilot study
is in healthy young adults without a history of chronic disease.

Inclusion Criteria:

- Frequent Cannabis Use (>3x/week for the prior 3 months) or

- No Cannabis Use (Less than 10x ever)

Exclusion Criteria:

- Sleep Apnea

- Pregnancy

- Diabetes

- Cardiovascular disease

- Chronic Pain

- History of seizures

- Severe Hepatic impairment

- Conditions associated with clinically relevant cognitive impairment

- Symptoms of acute or active illness (e.g., fever and leukocytosis)

- Evidence of psychopathology on the Beck Depression Index II (BDI-II or in a structured
clinical interview with a physician

- History of severe psychiatric illnesses (including such as alcoholism, drug dependency
including a cannabis use disorder score ≥12 on the Cannabis Use Disorders
Identification Test (CUDIT) (28) or >1 withdrawal symptom on the Marijuana Withdrawal
Checklist (MWC (29)) , major depression, manic depressive illness, schizophrenic
disorders, panic disorder, generalized anxiety disorder, post-traumatic stress
disorder, agoraphobia, claustrophobia, paranoid personality disorder, schizoid
personality disorder, schizotypal personality disorder, borderline personality
disorder, and antisocial personality disorder.)

- History of having been treated with antidepressants, neuroleptic medications, or
tranquilizers.

- Volunteers must be drug-free (including caffeine, nicotine, alcohol and herbal
medications) for the duration of the screening and study period (with the exception of
THC), with no history of drug (e.g. cocaine, opioids, amphetamine, methamphetamine,
PCP, benzodiazepines, barbiturates, methadone, MDMA); or alcohol dependency.

- Current Nicotine use ( or history of more than 5 'pack years' of smoking)

- Current use of prescription or over the counter medications

- History of shift work in the last 6 months

- Travel across >2 time zones during the month prior to the study

- Habitual bedtime after 1am or waketime before 5am