The Impact of Three Distinct Exercise Types on Fatigue, Anxiety, and Depression in Parkinson's Disease



Status:Recruiting
Conditions:Depression, Parkinsons Disease
Therapuetic Areas:Neurology, Psychiatry / Psychology
Healthy:No
Age Range:18 - 75
Updated:2/13/2019
Start Date:February 11, 2019
End Date:October 2, 2019
Contact:Mary Feldman, DO
Email:msfeldman@premierhealth.com
Phone:(937) 438-7500

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The purpose of the study is to learn about the impact of exercise on fatigue, anxiety, and
depression in Parkinson's disease. It is well established that exercise improves the motor
symptoms of Parkinson's disease. However, it is not clear which types of exercise are most
beneficial for specific non-motor symptoms.

This is a multi-site trial (12 patients in each site). The investigators are recruiting 24
patients who will be randomized into either a spinning class, yoga class, dance class, or no
exercise intervention. Classes will be conducted twice a week for 6 weeks total at times
convenient for the patients. Patients will also be asked to complete questionnaires after
exercise classes to see if the exercise intervention improves measures of fatigue, anxiety,
and depression - and what exercise intervention may be superior. All participants will be
asked to complete questionnaires each week and will be asked to wear a "Microsoft exercise
band" during the course of the study. Use of the exercise band is optional.

Inclusion Criteria:

1. Subjects diagnosed with Idiopathic Parkinson's Disease

2. Age between 18 - 75 years

3. Hoehn and Yahr stage less than or equal to 3

4. Mini-Mental State Exam (MMSE) score of over 23 at screening

5. If subjects are taking any medications for depression, fatigue, or anxiety, regimen
must be stable for 8 weeks prior to baseline visit

6. Subjects willing and able to give informed consent

Exclusion Criteria:

1. Subjects with a diagnosis of an atypical Parkinsonism

2. Subjects unwilling or unable to obtain Health Waiver from Primary Care Provider

3. Score of 60 or more on UPDRS III at screening

4. Scores in the 'normal' range on all three study assessments: Beck Depression Index II,
Fatigue Severity Scale, and Zung self-rating Anxiety Scale

5. Participation in any of the 3 physical activities more than 3 times in the past for 8
weeks prior to baseline

6. Any other reason that, in the investigator's opinion, would exclude the subject from
participation in the study
We found this trial at
2
sites
Dayton, Ohio 45409
Principal Investigator: Mary Feldman, DO
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Phone: 603-650-5104
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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