Closure Of Patent Ductus Arteriosus With the AMPLATZER Duct Occluder the AMPLATZER® Duct Occluder

Inclusion Criteria:

- Patients with a demonstrated patent ductus arteriosus

- Body weight > 5 Kilograms

Exclusion Criteria:

- Pulmonary vascular resistance above 8 Woods units or a Rp/Rs >0.4.

- Additional cardiac or non-cardiac abnormality that can reasonably be expected to
significantly affect the patient's health adversely in the next two years, i.e.:
cancer, Eisenmenger's syndrome, other serious congenital heart disease.

- Pelvic vein or inferior vena cava thrombosis

- Sepsis (local/generalized) or any type of infection that cannot be successfully
treated prior to device placement.

- History of repeated pulmonary infection

- Demonstrated intracardiac thrombi on echocardiography • Inability to obtain informed
consent