Synergistic Activity of Human Milk Nutrients and Infant Cognition
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | Any - 35 |
| Updated: | 2/14/2019 |
| Start Date: | February 5, 2019 |
| End Date: | February 2025 |
| Contact: | Lerin Eason, BA |
| Email: | Lerin_eason@unc.edu |
| Phone: | 704-250-5038 |
Synergistic Activity of Choline, Lutein, and Docosahexaenoic Acid in Human Milk in Support of Cognitive Development: An Egg Intervention Feasibility Study
Purpose: To establish a whole food, egg, as a viable study material to supplement mothers and
infants with nutrients that support optimal brain development. There will be 84 breastfeeding
dyads, 3 months postnatal.
Mothers will be randomized to a whole egg or egg white (due to lack of an appropriate control
food). Initial diet intake will be screened using the NCI's ASA24 24h Dietary Assessment
Tool. Participants will come to the lab 4 times across 3 months (enrollment, 3 months, 4.5
months, and 6 months). Milk, saliva, and plasma will be collected from the mother, while
saliva and plasma (heel stick) are collected from the infant. Diet data will be collected at
each visit. The infant will complete a recognition memory test using electrophysiology at 6
months as well as the Bayley Scales of Infant Development at 4.5 months. The mother will
complete a temperament questionnaire at 3 months and 6 months.
infants with nutrients that support optimal brain development. There will be 84 breastfeeding
dyads, 3 months postnatal.
Mothers will be randomized to a whole egg or egg white (due to lack of an appropriate control
food). Initial diet intake will be screened using the NCI's ASA24 24h Dietary Assessment
Tool. Participants will come to the lab 4 times across 3 months (enrollment, 3 months, 4.5
months, and 6 months). Milk, saliva, and plasma will be collected from the mother, while
saliva and plasma (heel stick) are collected from the infant. Diet data will be collected at
each visit. The infant will complete a recognition memory test using electrophysiology at 6
months as well as the Bayley Scales of Infant Development at 4.5 months. The mother will
complete a temperament questionnaire at 3 months and 6 months.
Inclusion Criteria:
- infant is 12-15 weeks of age at enrollment
- healthy, lactating mother age 18-35
- gave birth at >38 weeks gestation without remarkable incident
- consuming <=50% of the recommended amounts of 2 of the 3, DHA, choline, and lutein
Exclusion Criteria:
- infant with diagnosis or documented suspicion of developmental delay
- BMI>29.9 in mother
- egg allergy or family history of egg allergy
- gestational diabetes
- any documented seizure activity
We found this trial at
1
site
Kannapolis, North Carolina 28081
Principal Investigator: Carol L Cheatham, Ph.D.
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