Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors

Bladder tumor recurrence after resection of non-muscle invasive bladder cancer (NMIBC) occurs
in 50-70% of patients despite the use of adjuvant anticancer therapy after surgery. This is a
single-arm, non-randomized pilot study looking to determine whether post-Transurethral
Resection of Bladder Tumor (TURBT) cells counts differ significantly between continuous
washout of the bladder (CBI) with normal saline compared to pre-CBI wash out. Anticipated
decrease in tumor recurrence and/or progression rates will also be measured, and each
participant will act as their own internal control.

Inclusion Criteria:

- Patients age 18 years and older diagnosed with a bladder mass on cystoscopy or imaging
study

- Primary bladder tumor occurrence

Exclusion Criteria:

- Patients with unresectable bladder tumors, as determined at the time of diagnosis or
TURBT , or imaging concerning of T2 or higher disease

- Patients with bladder perforation at the time of TURBT, which is a contraindication to
CBI

- Patients from vulnerable populations, including but not limited to impaired subjects,
pregnant women, prisoners, family members of the study team

- Any previous history of bladder tumor resection or intravesical
chemotherapy/immunotherapy

- History of previous pelvic radiation

- Bladder tumor volume > 5 cm, involvement of prostatic urethra, or any evidence of
hydronephrosis on imaging