Use of a Hyperinsulinemic-hypyglycemic Clamp to Study Hypoglycemia: a Method Development Study



Status:Recruiting
Conditions:Endocrine
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 40
Updated:2/17/2019
Start Date:November 28, 2018
End Date:October 16, 2019
Contact:David McDougal
Email:david.mcdougal@pbrc.edu
Phone:2257630278

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Trial Summary
Trial Overview
Inclusion Criteria
A hyperinsulinemic-hypoglycemic clamp is an experimental procedure, which allows for
hypoglycemia to be studied in a safe and controlled manner. The goal of this study is to
establish the hyperinsulinemic-hypoglycemic clamp procedure at Pennington Biomedical Research
Center in order to apply the knowledge gained to future studies which will determine the
efficacy of our biomarker for predicting susceptibility to hypoglycemia. Additionally, our
use of continuous glucose monitoring (CGM) during the clamp procedure will provide novel data
regarding the accuracy of CGM during hypoglycemic conditions in a controlled research
setting.


Inclusion Criteria:

- Healthy male or female

- Ages 18-40 years

- BMI between 20 kg/m2 and 30 kg/m2 (±0.5 kg/m2 will be accepted)

- Medically cleared for participation in the study

Exclusion Criteria:

- History of clinically diagnosed diabetes or a fasting blood glucose >126 mg/dL

- Average screening blood pressure >140/90 mmHg

- History of cardiovascular disease

- Pregnant, planning to become pregnant, or breastfeeding

- Based on the investigative team's clinical judgement, a subject may not be appropriate
for participation in the study.
We found this trial at
1
site
Pennington Biomedical Research Center
6400 Perkins Rd
Baton Rouge, Louisiana 70808
(225) 763-2500
Phone: 225-763-3000
Pennington Biomedical Research Center Unlike other medical research facilities where science occurs in separate labs...
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from
Baton Rouge, LA
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