ET-01 in Subjects With Lateral Canthal Lines, LCL-208

This product is being tested for its ability to reduce lateral canthal lines, also known as
Crow's Feet.

Inclusion Criteria:

- females 25 - 65 years of age

- minimal to moderate Crow's Feet wrinkles at rest

- moderate to severe Crow's Feet on contraction

- adequate vision to assess facial wrinkles in a mirror

- willingness to refrain from products affecting skin remodeling

- female subjects must be not pregnant and non-lactating

- subjects should be in good general health

Exclusion Criteria:

- history of adverse reactions to any prior botulinum toxin treatments

- history of vaccination or non-response to any prior botulinum toxin treatments

- botulinum toxin treatment in the prior 6 months

- present or history of neuromuscular disease, eyelid ptosis, muscle weakness,
paralysis, or "dry eye"

- history of peri-ocular surgery, brow lift or related procedures

- procedures affecting the lateral canthal region in the prior 12 months

- application of topical prescription medication to the treatment area

- female subjects who are pregnant or are nursing a child