Nutrition Interventions for Cognitive Enhancement
| Status: | Recruiting |
|---|---|
| Conditions: | Alzheimer Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 65 - Any |
| Updated: | 3/27/2019 |
| Start Date: | March 7, 2019 |
| End Date: | February 2023 |
| Contact: | Juleah Littrell, MS, RD, LD |
| Email: | jlittrell2@kumc.edu |
| Phone: | 913-588-6392 |
Enhanced Mediterranean Diet for Alzheimer's Disease Prevention
By doing this study, researchers hope to learn how the Mediterranean and low-fat eating
patterns affect memory, brain volume, brain antioxidant status and cardio-metabolic
biomarkers, such as blood pressure and blood glucose, in cognitively normal older adults.
Researchers also plan to examine underlying processes relating the patterns to brain health.
patterns affect memory, brain volume, brain antioxidant status and cardio-metabolic
biomarkers, such as blood pressure and blood glucose, in cognitively normal older adults.
Researchers also plan to examine underlying processes relating the patterns to brain health.
Participants will be randomized to either a Mediterranean or low-fat eating pattern.
Participation in the study will last about 13 months. Each person will be prescribed one of
two eating patterns for 12 months. During the study, participants will be asked to track the
food they eat and will be monitored by a registered dietitian. Participants will engage in
monthly food demonstrations and cooking classes. Participants will pick up a bag of food
items belonging to the prescribed eating pattern, on a weekly basis for 6 months, from a
local grocery store chain.
Participants have the option to continue in the study for up to 2 years for additional
measurements.
Potential participants need to be located within the Kansas City metro area.
Participation in the study will last about 13 months. Each person will be prescribed one of
two eating patterns for 12 months. During the study, participants will be asked to track the
food they eat and will be monitored by a registered dietitian. Participants will engage in
monthly food demonstrations and cooking classes. Participants will pick up a bag of food
items belonging to the prescribed eating pattern, on a weekly basis for 6 months, from a
local grocery store chain.
Participants have the option to continue in the study for up to 2 years for additional
measurements.
Potential participants need to be located within the Kansas City metro area.
Inclusion Criteria:
- Cognitively normal older adults over the age of 65 (MMSE score > 25; AD8 score of 2 or
less; no prior diagnosis of MCI, AD or dementia; and not medically treated for
cognitive impairment or dementia)
- Speak English as a primary language
- Live in the Kansas City, Metropolitan area
- Body Mass Index (BMI) range between 20 - 40 kg/m2
Exclusion Criteria:
- Serious medical risk, such as type 1 diabetes mellitus, cancer, recent cardiac event
(e.g. heart attach, angioplasty)
- Taking the prescription drug Warfarin
- Nut allergy, fish allergy (does not include shellfish)
- Adherence to specialized diet regimen (e.g., vegan, etc.)
- Evidence of severe major depression (GDS-SF > 5) or presence of a major psychiatric
disorder that in the investigator's opinion, could interfere with adherence to
research assessments or procedures
- Alcohol (over 3 drinks per day or total of 18 per week) or drug abuse
- Unwilling to be randomized to one of two diet interventions
- Do not have access to or independence over grocery shopping and meal preparation (i.e.
those in military, retirement community with reliance on dining facilities for meals)
- Already consume a Mediterranean diet
- Already consume a low-fat diet
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