Combined tDCS and Cognitive Training to Reduce Impulsivity in Patients With Traumatic Brain Injury
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital, Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/20/2019 |
| Start Date: | January 8, 2019 |
| End Date: | July 2020 |
| Contact: | Casey S Gilmore, PhD |
| Email: | casey.gilmore2@va.gov |
| Phone: | 612-467-2261 |
Behavioral changes following a traumatic brain injury (TBI) are one of the biggest challenges
for patients, as well as their family members and others involved in their recovery. One of
the most common behavioral changes following TBI is the emergence of impulsive behavior,
which has been associated with destructive, suicidal, and aggressive behavior, and is related
to poor rehabilitation program adherence. The primary objective of this study is to
investigate the effect of a novel neuroplasticity based intervention that combines cognitive
training and transcranial direct current stimulation (tDCS) to reduce impulsivity and to
improve outcomes and quality of life for those who have suffered a TBI.
for patients, as well as their family members and others involved in their recovery. One of
the most common behavioral changes following TBI is the emergence of impulsive behavior,
which has been associated with destructive, suicidal, and aggressive behavior, and is related
to poor rehabilitation program adherence. The primary objective of this study is to
investigate the effect of a novel neuroplasticity based intervention that combines cognitive
training and transcranial direct current stimulation (tDCS) to reduce impulsivity and to
improve outcomes and quality of life for those who have suffered a TBI.
Behavioral changes following a traumatic brain injury (TBI) are one of the biggest challenges
for patients, as well as their family members and others involved in their recovery. One of
the most common behavioral changes following TBI is the emergence of impulsive behavior,
which has been associated with destructive, suicidal, and aggressive behavior, and is related
to poor rehabilitation program adherence. The primary objective of this study is to
investigate the effect of a novel neuroplasticity based intervention approach utilizing
transcranial direct current stimulation (tDCS) to alter brain neuroplasticity combined with
cognitive training tasks selected to functionally target cognition and brain circuits that
are impaired in those TBI patients with impulsive behavior.
This double-blind, randomized, placebo (sham) controlled study will recruit 30 Veterans with
a history of mild, moderate or severe TBI, who exhibit a variety of impulsive behaviors.
Participants will be randomly assigned to receive either active or sham tDCS, both paired
with cognitive training tasks, once a day for five days. Additionally, participants will
attend three follow up visits at 1, 2, and 3 months after the course of intervention visits
is completed. Functional magnetic resonance imaging (fMRI) will be collected before and after
intervention, to measure brain activity changes across time depending on intervention type.
for patients, as well as their family members and others involved in their recovery. One of
the most common behavioral changes following TBI is the emergence of impulsive behavior,
which has been associated with destructive, suicidal, and aggressive behavior, and is related
to poor rehabilitation program adherence. The primary objective of this study is to
investigate the effect of a novel neuroplasticity based intervention approach utilizing
transcranial direct current stimulation (tDCS) to alter brain neuroplasticity combined with
cognitive training tasks selected to functionally target cognition and brain circuits that
are impaired in those TBI patients with impulsive behavior.
This double-blind, randomized, placebo (sham) controlled study will recruit 30 Veterans with
a history of mild, moderate or severe TBI, who exhibit a variety of impulsive behaviors.
Participants will be randomly assigned to receive either active or sham tDCS, both paired
with cognitive training tasks, once a day for five days. Additionally, participants will
attend three follow up visits at 1, 2, and 3 months after the course of intervention visits
is completed. Functional magnetic resonance imaging (fMRI) will be collected before and after
intervention, to measure brain activity changes across time depending on intervention type.
Inclusion Criteria:
Participants will be included in the study if they:
- have a clinical history of impulsive behavior, including substance abuse, gambling
problems, legal issues such as DUI, violent acts, aggression, history of suicidality,
or ADHD as assessed by the patient's clinical provider and/or screen of medical
records
- are age 18 or older
- are receiving services from the Minneapolis VA Health Care System
- are stable on any medications for at least 1 week at the baseline visit
- have a diagnosis of mild, moderate, or severe TBI (as defined by VA/DoD Clinical
Practice Guidelines criteria)
Exclusion Criteria:
Persons will be excluded from this study if they:
- have a significant neurological disorder based on the Principal Investigators judgment
that would impact risk
- diagnosed with current active psychosis or mania
- have metallic cranial plates/screws or implanted devices
- have eczema on scalp or other scalp lesions or skin disorders that may become
irritated by stimulation
- are pregnant
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