Cognitive Enhancement Through Transcranial Laser Therapy

The goal of this project is to test the efficacy of LLLT to enhance neurocognitive function
in middle-aged adults and examine the modulating influences of carotid atherosclerosis. The
specific aims will be accomplished in a randomized controlled trial (RCT) by examining
cognitive test performance and blood oxygen level-dependent (BOLD) response to a working
memory task in middle-aged and older adults and participants with Mild Cognitive Impairment
pre- and post- six-week long intervention of LLLT or placebo. In addition, the investigators
will examine if carotid artery intima-media thickness (IMT) moderates the therapeutic effects
of LLLT.

Inclusion Criteria:

- Men and postmenopausal women, aged 45 and older

- Participants with Mild Cognitive Impairment

Exclusion Criteria:

- neurological disease (e.g., large vessel stroke, seizure disorder, Parkinson's
disease, Alzheimer's disease, clinically significant traumatic brain injury with loss
of consciousness > 30 minutes, multiple sclerosis, or brain infection/meningitis

- baseline IQ < 85 placing them below the average range of intellectual functioning

- major psychiatric illness (e.g., schizophrenia, bipolar disorder) or substance abuse
(diagnosed abuse and/or previous hospitalization for substance abuse)

- severe cardiovascular disease (e.g., pacemaker), chronic obstructive pulmonary
disease, liver or kidney disease, inflammatory illness