A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer

Inclusion Criteria:

1. Known BRCA1 or BRCA2, TP53, PALB2 carrier. Women with pathogenic mutations in any
other cancer susceptibility genes are eligible only if they also have a high PRS.

2. With life time risk of 40% or higher, based on Polygenic Risk Score that integrates
genetic and non-genetic factors.

3. Without prior breast cancer.

4. Must be older than 21 years.

5. Willing to travel to University of Chicago Medical Center for imaging studies as well
as any necessary follow-up procedures.

6. Be able to give informed consent.

Exclusion Criteria

1. Active cancer at the time of enrollment.

2. Current pregnancy or plans for pregnancy within two years of enrollment.

3. Presence of a pacemaker or any other metallic foreign objects in their body that
interferes with an MRI.

4. Breast surgery within two weeks of study entry.

5. History of kidney disease or abnormal kidney function.

- Women can be taking hormone replacement therapy, tamoxifen, raloxifene, aromatase
inhibitors or participating in a chemoprevention trial.