NeoMatriX Wound Matrix Collagen Dressing Skin Prick Test

Using a minimally invasive skin prick test, the test material, positive control, and negative
control are applied to the forearm using a prick test. The test area is observed after 15
minutes, 6 hours, and again at 1-2 days after the initial prick test. The skin will be
examined for a reaction such as a wheal and/or a flare, a flare alone is not clinically
significant.

Inclusion Criteria:

- Healthy volunteers aged at least 18 years.

- Completed written informed consent and receive a copy of their executed ICF.

- Volunteers must be capable of understanding and following directions in English.

Exclusion Criteria:

- Pregnancy or lactation;

- Inadequate or non-existent contraception (women of child bearing potential only);

- A current skin disease;

- Heavy alcohol consumption;

- Current use or history of repeated use of recreational drugs;

- Recent illness prior to test;

- Significant past medical history of diseases to potentially effect study results;

- Current treatment of allergy;

- A history of multiple drug hypersensitivity;

- Concurrent medication likely to affect the response to the test articles or confuse
the results of the study;

- Known sensitivity to the test articles;

- Participation in a repeat insult patch test (RIPT), skin prick test (SPT) or follow-up
work within the last month;

- Sensitization or questionable sensitization in a skin test;

- Recent immunization.