Symptom Management Implementation of Patient Reported Outcomes in Oncology

A multi-disciplinary team of investigators from 6 health systems have formed the Symptom
Management IMplementation of Patient Reported Outcomes in Oncology (SIMPRO) Research Center.
SIMPRO will use functioning ePRO prototypes to create and refine the electronic symptom
management system eSyM. eSyM is the name of the platform the team will refine, integrate,
implement and evaluate. eSyM addresses each of the 4 evidence gaps by:

- Implementing eSyM in cancer centers in small, rural or community-based systems.

- Integrating eSyM into the EHR of the predominant vendor used nationwide.

- Leveraging evidence-based tools, patient engagement, and population management.

- Executing this work using the Consolidated Framework for Implementation Research across
all phases to maximize the chances that eSyM and similar systems achieve their intended
goals and decrease the morbidity of cancer treatment at a population level.

This project contains 4 activities:

1. Obtain stakeholder feedback

2. Build and deploy eSyM

3. Pilot test eSyM

4. Pragmatic stepped-wedge cluster randomized trial

Inclusion Criteria:

Activity 1 Population:

- Age ≥ 18 years

- The potential stakeholders are: patient advisory council members, health system
leaders, clinicians, clinic support staff/administration, IT/Informatics staff

Activity 3 Population:

- Age ≥ 18 years

- Priority population will be patients who meet one of the following:

- Diagnosis of thoracic cancer [lung or bronchus] AND is inpatient following
thoracic cancer surgery.

- Diagnosis of gastrointestinal cancer [colorectal, pancreas, liver/biliary,
esophagus,or gastric] AND is inpatient following gastrointestinal cancer surgery.

- Diagnosis of gynecologic cancer [ovary, uterus, or cervix] AND is inpatient
following gynecologic cancer surgery.

- Diagnosis of thoracic cancer [lung or bronchus] AND scheduled to start a new
palliative chemotherapy regimen for thoracic cancer.

- Diagnosis of gastrointestinal cancer [colorectal, pancreas, liver/biliary,
esophagus,or gastric] AND scheduled to start a new palliative chemotherapy
regimen for gastrointestinal cancer.

- Diagnosis of gynecologic cancer [ovary, uterus, or cervix] AND scheduled to start
a new palliative chemotherapy regimen for gynecologic cancer.

- Total population allowed to use eSyM:

- Any cancer patient at any participating site.

Activity 4 Population:

- Age ≥ 18 years

- Priority population will be patients who meet one of the following:

- Diagnosis of thoracic cancer [lung or bronchus] AND is inpatient following
thoracic cancer surgery.

- Diagnosis of gastrointestinal cancer [colorectal, pancreas, liver/biliary,
esophagus,or gastric] AND is inpatient following gastrointestinal cancer surgery.

- Diagnosis of gynecologic cancer [ovary, uterus, or cervix] AND is inpatient
following gynecologic cancer surgery.

- Diagnosis of thoracic cancer [lung or bronchus] AND scheduled to start a new
palliative chemotherapy regimen for thoracic cancer.

- Diagnosis of gastrointestinal cancer [colorectal, pancreas, liver/biliary,
esophagus,or gastric] AND scheduled to start a new palliative chemotherapy
regimen for gastrointestinal cancer.

- Diagnosis of gynecologic cancer [ovary, uterus, or cervix] AND scheduled to start
a new palliative chemotherapy regimen for gynecologic cancer.

- Total population allowed to use eSyM:

- Any cancer patient at any participating site.