Dietary Intervention and Gastrointestinal Function in Patients With Parkinson's Disease

Inclusion Criteria:

- Physician-diagnosed Parkinson's disease aged 21-85 years

- Hoehn & Yahr stage <3

- Lives within the Gainesville, Lake City, Ocala areas

- Willing and able to complete informed consent in English

- Willing to complete daily and weekly questionnaires and 6 dietary recalls over
approximately 7 weeks

- Willing to avoid beer, wine, and cocktails on the day before and the day of the sugar
probe tests.

- Willing to provide urine and stool samples during the study collection periods.

- Willing and able to fast (no food or drink, except water or tea) for a prolonged
period of time during study urine collections.

- Willing to maintain usual diet through the pre-baseline period

- Willing to make dietary changes to follow a Mediterranean dietary pattern during the
intervention period.

- Willing to discontinue taking prebiotic, fiber, probiotic, herbal, or high-dose
vitamin or mineral supplements that may impact inflammation during the pre-baseline
period and throughout the study protocol.

- Willing to limit use of oral laxative medication to an "as-needed basis" (i.e. <3
times per week) during the full length of the study

- Willing to avoid high intensity exercises two days prior to and the day of the
permeability tests. These tests will be done on two occasions.

- Willing to provide a social security number to receive study payment.

Exclusion Criteria:

- Does not meet above criteria

- Atypical or secondary Parkinsonism

- History of deep brain stimulation

- Daily use of systemic corticosteroids, androgens (such as testosterone), or NSAIDs in
the last 3 months or incidental use in the last 2 weeks prior to screening.

- Daily use of anticholinergics or prokinetic agents

- Use of enemas or suppositories to alleviate constipation

- Use of another investigational product within 3 months of the screening visit.

- Antibiotic use within 2 months from the day of stool collection

- Good adherence to the Mediterranean diet during the pre-baseline period (score >6)
based on the 14-item Mediterranean Diet Assessment Tool

- Physician-diagnosed gastrointestinal disease or condition (such as ulcerative colitis,
Crohn's disease, gastroparesis, cancer, peptic ulcer disease, Celiac disease, short
bowel disease, ileostomy, colostomy) other than gastroesophageal reflux or
diverticular disease