Personalized Smoking Cessation Tool Based on Patient Lung CT Image

Imbio is developing a Smoking Cessation Report (Report) that includes data analysis from a CT
lung cancer screening exam. This randomized controlled (RCT) trial will clinically validate
the Report's impact on: (a) Lung screening participants' motivation to make a quit attempt by
calling a Quitline, and (b) the effectiveness of a 45-minute telephone smoking cessation
counseling session for motivating an actual quit attempt and abstinence. The RCT will enroll
approximately 400 randomly selected participants from lung screening programs at
HealthPartners and University of Michigan. Participants will be randomly assigned to one of
four conditions: 1) Usual Care + quitline phone number (created specifically for the trial
and maintained for the length of the trial); 2) Usual Care + Report (Report will list
Quitline number) 3) Usual Care + Counseling, or 4) Usual Care + Report + Counseling. Follow
up assessment calls will be conducted with participants at three weeks, three months, and six
months following the mailing of the report.

Inclusion Criteria:

- 30-pack year smoking history

- currently smoke OR quit within the last 15 years and a category 1 or 2 Lung-RADS scan

Exclusion Criteria:

- current use of smoking cessation medications

- scan read as a category 3, 4A, 4B or 4X in Lung-RADS

- unstable medical or psychiatric conditions

- current alcohol or drug use disorder

- past-month suicidal ideation

- past-year suicide attempt