Combination Chemotherapy With or Without Rituximab in Treating Participants With Stage III-IV Classic Hodgkin Lymphoma

PRIMARY OBJECTIVES:

I. To evaluate the event free survival (EFS) following therapy with rituximab plus adriamycin
(doxorubicin hydrochloride), bleomycin, vinblastine, and dacarbazine (ABVD) or standard ABVD
in patients with newly diagnosed classical Hodgkin lymphoma who have poor prognosis defined
as International prognostic score (IPS) of > 2.

SECONDARY OBJECTIVES:

I. To compare the effect of the two treatment arms on positron emission tomography (PET) scan
results after 2 cycles of therapy.

II. To compare the effect of the two treatment arms on the level of circulating malignant
Hodgkin stem cells.

OUTLINE: Participants are randomized to 1 of 2 arms.

ARM A: Participants receive rituximab intravenously (IV) over 7 hours on days 1, 8, 15, and
22 of course 1 and on days 1 and 8 of course 2. Participants also receive doxorubicin
hydrochloride, bleomycin, vinblastine, and dacarbazine IV over 1 hour on days 1 and 15.
Treatment with ABVD repeats every 4 weeks for up to 6 courses in the absence of disease
progression or unacceptable toxicity.

ARM B: Participants receive doxorubicin hydrochloride, bleomycin, vinblastine, and
dacarbazine as in Arm A.

After completion of study treatment, participants are followed up every 3 months for the
first year, every 4 months for the second year, every 6 months for years 3-5, and then
annually thereafter.

Inclusion Criteria:

- Previously untreated patient with classical Hodgkin's lymphoma patients with stage III
and IV

- International Prognostic Score of > 2 (patient must have > 2 of the following risk
features: Male, >= 45 years of age, stage IV, albumin < 4, white blood cell count
[WBC] >= 15, lymphocytes < 8% or < 600, hemoglobin [Hgb] < 10.5)

- Must sign a consent form

- Absolute neutrophil count (ANC) >= 1,500/microL

- Platelet > 100,000/microL

- Left ventricular ejection fraction (LVEF) >= 50% by multigated acquisition (MUGA) scan
or echocardiogram

- Serum creatinine < 2 mg/dl

- Serum bilirubin < 2 mg/dl

- Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2 x upper limit
of normal (ULN)

- Bi-dimensionally measurable disease

Exclusion Criteria:

- Lymphocyte predominant Hodgkin's lymphoma

- Known human immunodeficiency virus (HIV) infection

- Pregnant women and women of child bearing age who are not practicing adequate
contraception

- Prior chemotherapy or radiation therapy

- Severe pulmonary disease as judged by the principal investigator (PI) including
chronic obstructive pulmonary disease (COPD) and asthma

- Active infection requiring treatment with intravenous therapy

- Presence of central nervous system (CNS) lymphoma

- Concomitant malignancies or previous malignancies within the last 5 years (exception
made for adequately treated basal or squamous cell carcinoma of the skin or carcinoma
in situ of cervix)

- Active hepatitis B or C infection