Clinical Feasibility of Transcranial Direct Current Stimulation [tDCS] With Standard Aphasia Therapy
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Neurology, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 3/2/2019 |
| Start Date: | August 31, 2017 |
| End Date: | May 31, 2020 |
Study Design: This is a within-subjects crossover design. Subjects will participate in the
procedures twice, once under each condition (active vs. sham stimulation). The order of
conditions will be counter-balanced across subjects. Stimulation will target ventral inferior
frontal gyrus (IFG) and will be paired with standard speech-language therapy. Outcome
measures will be acquired at the beginning and end of a semester of standard speech-language
therapy, and at follow-up.
procedures twice, once under each condition (active vs. sham stimulation). The order of
conditions will be counter-balanced across subjects. Stimulation will target ventral inferior
frontal gyrus (IFG) and will be paired with standard speech-language therapy. Outcome
measures will be acquired at the beginning and end of a semester of standard speech-language
therapy, and at follow-up.
Baseline Behavioral Assessment: Medical and neurological history will be taken. Western
Aphasia Battery-Revised, Communication Activities of Daily Living-2, and Philadelphia Naming
Test (short form) will be administered. Narrative will be elicited (Cinderella story). Some
of these procedures will be videorecorded for later transcription. Subjects will also
complete a pre-tDCS safety screening questionnaire.
tDCS: Participants will undergo placement of 2 tDCS electrodes. For all subjects, the anodal
electrode will be placed at the following locations (EEG 10-20 system):
(i) over the left inferior frontal gyrus (crossing point between T3-Fz and F7-Cz)
The cathodal electrode will be placed at the second site:
(ii) over right frontal pole (Fp2)
Two types of stimulation will be given, an active condition and a sham condition. In the sham
condition, stimulation is ramped up over the first 30 seconds (as in the active condition),
but then discontinued. This gives the physical perception of stimulation without the
modulatory effects.
Stimulation will be delivered by a tDCS device with the following parameters for intensity
and duration:
- Intensity: 2 mA
- Duration: 20 minutes
tDCS will be provided for the first 20 minutes of each aphasia therapy session provided at
the LSU Speech-Language-Hearing Clinic. The therapy sessions last for one hour and are
provided twice weekly for 12 weeks over the course of an academic semester (fall and spring).
Post-Therapy/Stimulation Assessment: Western Aphasia Battery-Revised, Communication
Activities of Daily Living-2, and Philadelphia Naming Test (short form) will be administered
as before therapy. Cinderella narrative will again be elicited. Some of these procedures will
again be videorecorded for later transcription. A tDCS sensations survey will also be
completed at the final assessment to determine the effectiveness of blinding.
Aphasia Battery-Revised, Communication Activities of Daily Living-2, and Philadelphia Naming
Test (short form) will be administered. Narrative will be elicited (Cinderella story). Some
of these procedures will be videorecorded for later transcription. Subjects will also
complete a pre-tDCS safety screening questionnaire.
tDCS: Participants will undergo placement of 2 tDCS electrodes. For all subjects, the anodal
electrode will be placed at the following locations (EEG 10-20 system):
(i) over the left inferior frontal gyrus (crossing point between T3-Fz and F7-Cz)
The cathodal electrode will be placed at the second site:
(ii) over right frontal pole (Fp2)
Two types of stimulation will be given, an active condition and a sham condition. In the sham
condition, stimulation is ramped up over the first 30 seconds (as in the active condition),
but then discontinued. This gives the physical perception of stimulation without the
modulatory effects.
Stimulation will be delivered by a tDCS device with the following parameters for intensity
and duration:
- Intensity: 2 mA
- Duration: 20 minutes
tDCS will be provided for the first 20 minutes of each aphasia therapy session provided at
the LSU Speech-Language-Hearing Clinic. The therapy sessions last for one hour and are
provided twice weekly for 12 weeks over the course of an academic semester (fall and spring).
Post-Therapy/Stimulation Assessment: Western Aphasia Battery-Revised, Communication
Activities of Daily Living-2, and Philadelphia Naming Test (short form) will be administered
as before therapy. Cinderella narrative will again be elicited. Some of these procedures will
again be videorecorded for later transcription. A tDCS sensations survey will also be
completed at the final assessment to determine the effectiveness of blinding.
Inclusion Criteria:
- Single, unilateral stroke resulting in aphasia
- Competency to provide written informed consent
- Ability to participate in standard aphasia therapy
Exclusion Criteria:
- Serious psychological condition
- Serious neurological condition, other than stroke
- Serious medical condition
- Pregnancy
- History of seizures
- Presence of electronic or metal implants (e.g., pacemaker, vagal nerve stimulator,
etc.).
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