Activity and Balanced Eating to Reduce Comorbidities and Symptoms of MS
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 3/2/2019 |
| Start Date: | February 26, 2019 |
| End Date: | December 2019 |
| Contact: | Brooks C Wingo, PhD |
| Email: | bcwingo@uab.edu |
| Phone: | 205-934-5982 |
Comprehensive Lifestyle Intervention for Reducing Cardiometabolic Risk and Symptom Burden in Adults With Multiple Sclerosis
Multiple sclerosis (MS) is the leading cause of irreversible neurological disability among
young women and the second leading cause of disability among young men in the U.S.
Cardiometabolic risk factors including obesity and hyperlipidemia are common among people
with MS, and these risk factors are associated with severity and frequency of MS relapses and
disease progression. People with MS often experience symptoms of pain, fatigue, and
depression, which make adhering to a healthy lifestyle difficult, as evidenced by the high
rates of unhealthy behaviors including poor diet and physical inactivity among this group.
Physical activity has reduced symptoms of MS and improved metabolic risk profiles, but little
research has focused on the role of a dietary intervention combined with physical activity in
this group. Therefore, the purpose of this study is to test the efficacy of a combined diet
and physical activity intervention for reducing cardiometabolic risks and MS symptoms when
compared to a physical activity intervention alone.
young women and the second leading cause of disability among young men in the U.S.
Cardiometabolic risk factors including obesity and hyperlipidemia are common among people
with MS, and these risk factors are associated with severity and frequency of MS relapses and
disease progression. People with MS often experience symptoms of pain, fatigue, and
depression, which make adhering to a healthy lifestyle difficult, as evidenced by the high
rates of unhealthy behaviors including poor diet and physical inactivity among this group.
Physical activity has reduced symptoms of MS and improved metabolic risk profiles, but little
research has focused on the role of a dietary intervention combined with physical activity in
this group. Therefore, the purpose of this study is to test the efficacy of a combined diet
and physical activity intervention for reducing cardiometabolic risks and MS symptoms when
compared to a physical activity intervention alone.
Inclusion Criteria:
- Relapsing-Remitting MS
- On disease modifying treatment for 6 months
- No relapse within the previous 30 days
- BMI 25-55 kg/m2
- Self-identify as not currently meeting recommendations for healthy diet and physical
activity
- Ambulatory with or without assistance
- Reliable access to the internet via computer or smartphone
- Responsible for their personal food preparation or have input into the food prepared
for them
- Score indicating low cognitive functioning on the Telephone Interview for Cognitive
Status assessment
Exclusion Criteria:
- Physician does not approve participation
- Use of the following diabetes medications: Acetohexamide, Chlorpropamide (Diabinese),
Tolbutamide (Orinase, Tol-Tab), Tolazamide (Tolinase), Glipizide (Glucotrol, Glucotrol
XL, Metaglip), Glyburide (Micronase, DiaBeta, Glynase, Glucovance), Glimepiride
(Amaryl), Humalog or lispro, Novolog or aspart, Apidra or glulisine, Regular (R)
humulin or novolin, Velosulin (for use in the insulin pump), NPH (N), Lente (L),
Ultralente (U), Lantus, Levemir or detemir, Humulin 70/30, Novolin 70/30, Novolog
70/30, Humulin 50/50, or Humalog mix 75/25
- Already on a specific diet meant to improve health
- Heart attack, stroke, or heart bypass surgery less than 6 months ago
- Pulmonary disease, cardiovascular disease or renal failure less than 6 months ago
- Smoking
- Cancer, HIV or liver/kidney disease
- Inability to travel to Lakeshore for testing
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