Train Your Brain Clinical Trial
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 3/3/2019 |
| Start Date: | April 19, 2018 |
| End Date: | December 31, 2019 |
| Contact: | Garrett Weskamp |
| Email: | vetnfb@usc.edu |
| Phone: | 4242614968 |
Train Your Brain: A Neurofeedback Intervention for Individuals With Post-Traumatic Stress Disorder
The investigator's aim is to evaluate the efficacy of two types of neurofeedback treatments
for PTSD symptoms reduction. Half of the participants will receive the current standard for
PTSD neurofeedback care undergoing alpha/theta neurofeedback regulation. The other half will
receive the newly developed limbic modulation index neurofeedback.
for PTSD symptoms reduction. Half of the participants will receive the current standard for
PTSD neurofeedback care undergoing alpha/theta neurofeedback regulation. The other half will
receive the newly developed limbic modulation index neurofeedback.
Traumatic stress is commonly resistant to existing therapeutics, possibly due to high
treatment dropout rates along with a failure to target the relevant underlying neural
mechanisms. Neuromodulation of deep limbic areas such as the amygdala may play a critical
role in the effective recovery from traumatic stress. Human studies have shown the importance
of such modulation during the encoding of traumatic stimuli, showing greater amygdala
activation for subsequently remembered traumatic stimuli. In addition, a prospective study
among previously healthy soldiers showed that hyper-activation of the amygdala prior to
military traumatic exposure corresponded with more severe post-traumatic symptoms following
exposure.
Together these finding points to the amygdala as a plausible neuromodulation target for
preventive or early interventions of post-traumatic disturbances. Local neuromodulation of
the amygdala could improve treatment specificity and the overall intervention outcome.
The main goal of the suggested research is to further develop and implement a non-invasive,
portable and cost-effective brain-imaging tool that will provide individual on-line guidance
for amygdala modulation. This closed-loop brain training will enhance individual resilience
to and coping with potentially traumatic stress as well as alleviate consequential
psychopathologies.
treatment dropout rates along with a failure to target the relevant underlying neural
mechanisms. Neuromodulation of deep limbic areas such as the amygdala may play a critical
role in the effective recovery from traumatic stress. Human studies have shown the importance
of such modulation during the encoding of traumatic stimuli, showing greater amygdala
activation for subsequently remembered traumatic stimuli. In addition, a prospective study
among previously healthy soldiers showed that hyper-activation of the amygdala prior to
military traumatic exposure corresponded with more severe post-traumatic symptoms following
exposure.
Together these finding points to the amygdala as a plausible neuromodulation target for
preventive or early interventions of post-traumatic disturbances. Local neuromodulation of
the amygdala could improve treatment specificity and the overall intervention outcome.
The main goal of the suggested research is to further develop and implement a non-invasive,
portable and cost-effective brain-imaging tool that will provide individual on-line guidance
for amygdala modulation. This closed-loop brain training will enhance individual resilience
to and coping with potentially traumatic stress as well as alleviate consequential
psychopathologies.
Inclusion Criteria:
- Previous diagnosis of PTSD
- PTSD symptoms within the last 30 days
Exclusion Criteria:
- Any active psychosis or suicidal intent
- A severe traumatic brain injury (one in which consciousness was lost for greater than
6 hours)
- Any of the following neurological disorders: Parkinson's, Alzheimer's, Brain Tumor, or
Brain Lesion.
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