Evaluation of PET/MR in Patients Selected for Ablation Therapy

Healthy Volunteers

Inclusion Criteria:

- Subjects must be ≥21 and ≤80 years of age;

- Subjects must provide informed consent prior to study procedures;

Exclusion Criteria:

- Known structural heart disease (e.g. myocardial infarction);

- History of ventricular arrhythmia;

- Any contraindication to MRI and/or PET, including:

- Subjects with life vest;

- Subjects with implanted heart device (e.g. ICD, Pacemaker);

- Subjects with metallic fragment or foreign body;

- Subjects with other form of devices or prosthesis that are not MRI compatible, such as
insulin pump, joint replacement, hearing aid, cochlear implant, permanent
contraceptive devices, etc.;

- Claustrophobia;

- Relative or absolute contraindication to Dotarem contrast:

- history of renal disease including acute or chronic severe renal insufficiency
(glomerular filtration rate <60 mL/min/1.73m2);

- a history of diabetes mellitus, systemic lupus, multiple myeloma, nephrogenic systemic
fibrosis, and other co-morbidities;

- History of hypersensitive reactions to Dotarem and/or gadolinium contrast agent

- Any clinically significant acute or unstable physical or psychological disease, judged
by the investigators based on medical history or screening physical examination, to be
incompatible with the study;

- Any physical or psychological disease judged by the investigators to be incompatible
with the study, based on medical history or screening physical examination

- Radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the
prior 12 months);

- Female subjects only: Positive serum and/or urine pregnancy test, or lactating, or
possibility of pregnancy cannot be ruled out prior to dosing;

- Inability to provide written informed consent;

Arrhythmia Subjects:

Inclusion criteria

- Subjects must be ≥21 and ≤80 years of age;

- Subjects must provide informed consent prior to study procedures;

- History of scar-mediated ventricular arrhythmia scheduled for invasive EAM-guided
catheter ablation for clinical care

Exclusion criteria

- Any contraindication to MRI and/or PET, including:

- Subjects with life vest;

- Subjects with implanted heart device (e.g. ICD, Pacemaker);

- Subjects with metallic fragment or foreign body;

- Subjects with other form of devices or prosthesis that are not MRI compatible, such as
insulin pump, joint replacement, hearing aid, cochlear implant, permanent
contraceptive devices, etc.;

- Claustrophobia;

- Relative or absolute contraindication to Dotarem contrast:

- history of renal disease including acute or chronic severe renal insufficiency
(glomerular filtration rate <60 mL/min/1.73m2);

- history of diabetes mellitus, systemic lupus, multiple myeloma, nephrogenic systemic
fibrosis, and other co-morbidities;

- History of hypersensitive reactions to Dotarem and/or gadolinium contrast agent;Any
clinically significant acute or unstable physical or psychological disease, judged by
the investigators based on medical history or screening physical examination, to be
incompatible with the study;

- Any physical or psychological disease judged by the investigators to be incompatible
with the study, based on medical history or screening physical examination

- Radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the
prior 12 months);

- Female subjects only: Positive serum and/or urine pregnancy test, or lactating, or
possibility of pregnancy cannot be ruled out prior to dosing;

- Inability to provide written informed consent;