Post-op Ketamine Study
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 3/9/2019 |
| Start Date: | March 28, 2016 |
| End Date: | April 27, 2019 |
Evaluation of Post Operative Pain Following Primary Total Knee Arthroplasty (TKA) With Intraoperative Subanesthetic Ketamine Administration and Spinal Anesthesia
The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine
with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic
consumption. We hypothesize that sub-anesthetic ketamine will decrease post-operative pain
and narcotic consumption and may secondarily lead to shorter lengths of stay, faster
rehabilitation, improved postoperative outcomes and patient satisfaction.
with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic
consumption. We hypothesize that sub-anesthetic ketamine will decrease post-operative pain
and narcotic consumption and may secondarily lead to shorter lengths of stay, faster
rehabilitation, improved postoperative outcomes and patient satisfaction.
Inclusion Criteria:
- 18 - 85 years of age
- ASA I - IV
- Undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia
Exclusion Criteria:
- BMI over 40*
- Contraindication or allergy to opioid pain medication or ketamine*
- Daily opioid use for pain control before surgery in excess of systemic morphine
equivalent to 10 mg*
- Ejection fraction (EF) less than 30%
- Creatinine clearance less than 30 mL/min*
- History of chronic liver failure
- Desire for nerve block or general anesthesia
- Any neurologic or psychiatric disorder (including bipolar disorder, post traumatic
stress disorder, schizophrenia)
- Prior surgery on ipsilateral knee within the last 6 months
- Alcohol abuse
We found this trial at
1
site
Click here to add this to my saved trials
